|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0012860,
umls-concept:C0033681,
umls-concept:C0033684,
umls-concept:C0086418,
umls-concept:C0851285,
umls-concept:C0871261,
umls-concept:C1155874,
umls-concept:C1419245,
umls-concept:C1704632,
umls-concept:C1704928,
umls-concept:C1706817,
umls-concept:C2911692
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2002-4-24
|
|
pubmed:abstractText |
The ubiquitously expressed c-Abl tyrosine kinase is activated in the apoptotic response of cells to DNA damage. The mechanisms by which c-Abl signals the induction of apoptosis are not understood. Here we show that c-Abl binds constitutively to the mammalian homolog of the Schizosaccharomyces pombe Rad9 cell cycle checkpoint protein. The SH3 domain of c-Abl interacts directly with the C-terminal region of Rad9. c-Abl phosphorylates the Rad9 Bcl-2 homology 3 domain (Tyr-28) in vitro and in cells exposed to DNA-damaging agents. The results also demonstrate that c-Abl-mediated phosphorylation of Rad9 induces binding of Rad9 to the antiapototic Bcl-x(L) protein. The regulation of Rad9 by c-Abl in the DNA damage response is further supported by the demonstration that the interaction between c-Abl and Rad9 contributes to DNA damage-induced apoptosis. These findings indicate that Rad9 is regulated by a c-Abl-dependent mechanism in the apoptotic response to genotoxic stress.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-10359610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-10391249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-10391250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-10391251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-10574931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-10617621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-10620799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-10713044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-10852904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-10866655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-10891478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-10996309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-11077446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-1563350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-1850008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-2065352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-2198571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-3345522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-6809309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-6828386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-7410404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-7651539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-7794804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-7845468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-7926767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-8019001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-8164650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-8194526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-8524841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-8530447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-8598911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-8616716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-8632906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-8692274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-8717045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-8798604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-8805224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-8900110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-8918887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-8929531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-8943031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-8943238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-9037071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-9109492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-9168116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-9168117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-9192670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-9278511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-9312071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-9365241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-9461559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-9524127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-9660799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-9704409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-9705507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-9716408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-9735050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-9872989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-9916993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11971963-9988744
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0270-7306
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
22
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
