Source:http://linkedlifedata.com/resource/pubmed/id/11971181
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
16
|
| pubmed:dateCreated |
2002-4-23
|
| pubmed:abstractText |
The intermediate state of HTLV-1 infection, often found in individuals dually infected with Strongyloides stercoralis (S. stercoralis) and HTLV-1, is assumed to be a preleukemic state of adult T-cell leukemia (ATL). To investigate the effects of S. stercoralis superinfection on the natural history of HTLV-1 infection, we characterized peripheral blood samples of these individuals in Okinawa, Japan, an endemic area for both HTLV-1 and S. stercoralis and we studied effects of the parasite antigen on T-cells. The dually infected individuals showed a significantly higher provirus load and an increase in CD4(+)25(+) T cell population, with a significant, positive correlation. This increase was attributable to polyclonal expansion of HTLV-1-infected cells, as demonstrated by inverse-long PCR analysis of the integration sites. S. stercoralis antigen activated the IL-2 promoter in reporter gene assays, induced production of IL-2 by PBMC in vitro, and supported growth of IL-2 dependent cell lines immortalized by HTLV-1 infection or the transduction of Tax. Taken collectively, these results indicate that S. stercoralis infection induces polyclonal expansion of HTLV-1-infected cells by activating the IL-2/IL-2R system in dually infected carriers, an event which may be a precipitating factor for ATL and inflammatory diseases.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
|
| pubmed:issn |
0950-9232
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| pubmed:author |
pubmed-author:EtohKen-ichiroK,
pubmed-author:FujitaKoichiroK,
pubmed-author:HoriEitaroE,
pubmed-author:KamihiraShimeruS,
pubmed-author:KiyunaSusumuS,
pubmed-author:KojimaSomeiS,
pubmed-author:MatsuokaMasaoM,
pubmed-author:NakadaKiyonobuK,
pubmed-author:SatoYoshiyaY,
pubmed-author:SatohMasaoM,
pubmed-author:ShiromaYoshiyukiY,
pubmed-author:SugaharaKazuyukiK,
pubmed-author:TakaraMasahiroM,
pubmed-author:TanakaYuetsuY,
pubmed-author:TomaHiromuH,
pubmed-author:WatanabeToshikiT,
pubmed-author:YamaguchiKazunariK
|
| pubmed:issnType |
Print
|
| pubmed:day |
11
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2466-75
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:11971181-Animals,
pubmed-meshheading:11971181-Antigens, Helminth,
pubmed-meshheading:11971181-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11971181-Carrier State,
pubmed-meshheading:11971181-Cell Line,
pubmed-meshheading:11971181-Cells, Cultured,
pubmed-meshheading:11971181-Clone Cells,
pubmed-meshheading:11971181-Female,
pubmed-meshheading:11971181-HTLV-I Infections,
pubmed-meshheading:11971181-Human T-lymphotropic virus 1,
pubmed-meshheading:11971181-Humans,
pubmed-meshheading:11971181-Immunophenotyping,
pubmed-meshheading:11971181-Interleukin-2,
pubmed-meshheading:11971181-Lymphocyte Activation,
pubmed-meshheading:11971181-Male,
pubmed-meshheading:11971181-Middle Aged,
pubmed-meshheading:11971181-Proviruses,
pubmed-meshheading:11971181-Receptors, Interleukin-2,
pubmed-meshheading:11971181-Strongyloides stercoralis,
pubmed-meshheading:11971181-Strongyloidiasis,
pubmed-meshheading:11971181-T-Lymphocyte Subsets,
pubmed-meshheading:11971181-Viral Load
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Involvement of IL-2/IL-2R system activation by parasite antigen in polyclonal expansion of CD4(+)25(+) HTLV-1-infected T-cells in human carriers of both HTLV-1 and S. stercoralis.
|
| pubmed:affiliation |
Division of Pathology, Institute of Medical Science, University of Tokyo, Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|