|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2002-4-23
|
|
pubmed:abstractText |
Autoreactive B cells that appear to be inactivated can be found in healthy individuals. In this study, we examined the potential of these anergic cells to become activated. We show that anergy of anti-double-stranded DNA (dsDNA) B cells in BALB/c mice is readily reversed, requiring only the provision of T cell help. We further show that spontaneous loss of anergy among anti-dsDNA B cells in autoimmune lpr/lpr mice occurs in two phases: an abortive initial response to T help followed by full loss of tolerance. Strikingly, the abortive response can be reproduced in nonautoimmune mice when CD4+CD25+ T regulatory cells are administered in conjunction with CD4+ T helper cells, suggesting that loss of B cell tolerance may require both the production of T cell help and the overcoming of T suppression.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD40,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Blr1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/CD40 Ligand,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Ctla4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR5,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytokine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/abatacept
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1074-7613
|
|
pubmed:author |
pubmed-author:BucklerJodi LJL,
pubmed-author:CatonAndrew JAJ,
pubmed-author:EriksonJanJ,
pubmed-author:FieldsMichele LML,
pubmed-author:FinkelmanFred DFD,
pubmed-author:Mandik-NayakLauraL,
pubmed-author:NishSimone ASA,
pubmed-author:NoelleRandolph JRJ,
pubmed-author:ReedAmy JAJ,
pubmed-author:SeoSu-jeanSJ,
pubmed-author:TurkaLaurence ALA
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
16
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
535-46
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:11970877-Animals,
pubmed-meshheading:11970877-Antigens, CD,
pubmed-meshheading:11970877-Antigens, CD28,
pubmed-meshheading:11970877-Antigens, CD40,
pubmed-meshheading:11970877-Antigens, CD80,
pubmed-meshheading:11970877-Antigens, Differentiation,
pubmed-meshheading:11970877-B-Lymphocytes,
pubmed-meshheading:11970877-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11970877-CD40 Ligand,
pubmed-meshheading:11970877-CTLA-4 Antigen,
pubmed-meshheading:11970877-Cell Differentiation,
pubmed-meshheading:11970877-Clonal Anergy,
pubmed-meshheading:11970877-DNA,
pubmed-meshheading:11970877-Female,
pubmed-meshheading:11970877-Immunoconjugates,
pubmed-meshheading:11970877-Lymphocyte Activation,
pubmed-meshheading:11970877-Male,
pubmed-meshheading:11970877-Mice,
pubmed-meshheading:11970877-Mice, Inbred BALB C,
pubmed-meshheading:11970877-Mice, Inbred MRL lpr,
pubmed-meshheading:11970877-Mice, Transgenic,
pubmed-meshheading:11970877-Models, Immunological,
pubmed-meshheading:11970877-Receptors, CXCR5,
pubmed-meshheading:11970877-Receptors, Chemokine,
pubmed-meshheading:11970877-Receptors, Cytokine,
pubmed-meshheading:11970877-Receptors, Interleukin-2,
pubmed-meshheading:11970877-Spleen,
pubmed-meshheading:11970877-T-Lymphocytes, Helper-Inducer
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cells.
|
|
pubmed:affiliation |
The Wistar Institute, Philadelphia, PA 19104, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
