pubmed-article:11970735 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:11970735 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:11970735 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
pubmed-article:11970735 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
pubmed-article:11970735 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
pubmed-article:11970735 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
pubmed-article:11970735 | lifeskim:mentions | umls-concept:C1101704 | lld:lifeskim |
pubmed-article:11970735 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:11970735 | pubmed:dateCreated | 2002-4-23 | lld:pubmed |
pubmed-article:11970735 | pubmed:abstractText | Beta-endorphin and the synthetic beta-endorphin-like decapeptide Ser-Leu-Thr-Cys-Leu-Val-Lys-Gly-Phe-Tyr (referred to as immunorphin), corresponding to the sequence 364-373 of the CH3 domain of human immunoglobulin G heavy chain, were shown to stimulate concanavalin A-induced proliferation of T lymphocytes from the blood of healthy donors. [Met(5)]Enkephalin and the antagonist of opioid receptors naloxone examined in parallel were inactive. The stimulating effect of beta-endorphin and immunorphin on T lymphocyte proliferation is not inhibited by naloxone. Studies on receptor binding of (125)I-labeled immunorphin to T lymphocytes revealed that it binds with high affinity to naloxone-insensitive receptors (K(d) = 7.0 +/- 0.3 nM). Unlabeled immunorphin completely inhibits (125)I-labeled beta-endorphin specific binding to naloxone-insensitive receptors on T lymphocytes (K(i) = 0.6 +/- 0.1 nM). Thus, beta-endorphin and immunorphin interact with common naloxone-insensitive receptors on T lymphocytes. | lld:pubmed |
pubmed-article:11970735 | pubmed:language | eng | lld:pubmed |
pubmed-article:11970735 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11970735 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:11970735 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11970735 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11970735 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11970735 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11970735 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11970735 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11970735 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11970735 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11970735 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11970735 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11970735 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11970735 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11970735 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11970735 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11970735 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:11970735 | pubmed:month | Mar | lld:pubmed |
pubmed-article:11970735 | pubmed:issn | 0006-2979 | lld:pubmed |
pubmed-article:11970735 | pubmed:author | pubmed-author:LipkinV MVM | lld:pubmed |
pubmed-article:11970735 | pubmed:author | pubmed-author:NavolotskayaE... | lld:pubmed |
pubmed-article:11970735 | pubmed:author | pubmed-author:ZargarovaT... | lld:pubmed |
pubmed-article:11970735 | pubmed:author | pubmed-author:LepikhovaT... | lld:pubmed |
pubmed-article:11970735 | pubmed:author | pubmed-author:MalkovaN VNV | lld:pubmed |
pubmed-article:11970735 | pubmed:author | pubmed-author:KrasnovaS BSB | lld:pubmed |
pubmed-article:11970735 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:11970735 | pubmed:volume | 67 | lld:pubmed |
pubmed-article:11970735 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:11970735 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:11970735 | pubmed:pagination | 357-63 | lld:pubmed |
pubmed-article:11970735 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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pubmed-article:11970735 | pubmed:year | 2002 | lld:pubmed |
pubmed-article:11970735 | pubmed:articleTitle | Effect of synthetic beta-endorphin-like peptide immunorphin on human T lymphocytes. | lld:pubmed |
pubmed-article:11970735 | pubmed:affiliation | Branch of the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, pr. Nauki 6, Pushchino, Moscow Region, 142290 Russia. navolots@fibkh.serpukhov.su | lld:pubmed |
pubmed-article:11970735 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:11970735 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11970735 | lld:pubmed |