| pubmed-article:11968185 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11968185 | lifeskim:mentions | umls-concept:C0040113 | lld:lifeskim |
| pubmed-article:11968185 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:11968185 | lifeskim:mentions | umls-concept:C0282637 | lld:lifeskim |
| pubmed-article:11968185 | lifeskim:mentions | umls-concept:C1709634 | lld:lifeskim |
| pubmed-article:11968185 | pubmed:issue | 5567 | lld:pubmed |
| pubmed-article:11968185 | pubmed:dateCreated | 2002-4-22 | lld:pubmed |
| pubmed-article:11968185 | pubmed:abstractText | CD1d-restricted autoreactive natural killer (NK1.1+) T cells function as regulatory cells in various disease conditions. Using improved tetramer tracking methodology, we identified a NK1.1- thymic precursor and followed its differentiation and emigration to tissues by direct cell transfer and in situ cell labeling studies. A major lineage expansion occurred within the thymus after positive selection and before NK receptor expression. Surprisingly, cytokine analysis of the developmental intermediates between NK and NK+ stages showed a T helper cell TH2 to TH1 conversion, suggesting that the regulatory functions of NK T cells may be developmentally controlled. These findings characterize novel thymic and postthymic developmental pathways that expand autoreactive cells and differentiate them into regulatory cells. | lld:pubmed |
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| pubmed-article:11968185 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11968185 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11968185 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11968185 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11968185 | pubmed:issn | 1095-9203 | lld:pubmed |
| pubmed-article:11968185 | pubmed:author | pubmed-author:BendelacAlber... | lld:pubmed |
| pubmed-article:11968185 | pubmed:author | pubmed-author:BenlaghaKamel... | lld:pubmed |
| pubmed-article:11968185 | pubmed:author | pubmed-author:TeytonLucL | lld:pubmed |
| pubmed-article:11968185 | pubmed:author | pubmed-author:KyinTimT | lld:pubmed |
| pubmed-article:11968185 | pubmed:author | pubmed-author:BeavisAndrewA | lld:pubmed |
| pubmed-article:11968185 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:11968185 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:11968185 | pubmed:volume | 296 | lld:pubmed |
| pubmed-article:11968185 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11968185 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11968185 | pubmed:pagination | 553-5 | lld:pubmed |
| pubmed-article:11968185 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:11968185 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11968185 | pubmed:articleTitle | A thymic precursor to the NK T cell lineage. | lld:pubmed |
| pubmed-article:11968185 | pubmed:affiliation | Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. | lld:pubmed |
| pubmed-article:11968185 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11968185 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11968185 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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