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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5567
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pubmed:dateCreated |
2002-4-22
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pubmed:abstractText |
CD1d-restricted autoreactive natural killer (NK1.1+) T cells function as regulatory cells in various disease conditions. Using improved tetramer tracking methodology, we identified a NK1.1- thymic precursor and followed its differentiation and emigration to tissues by direct cell transfer and in situ cell labeling studies. A major lineage expansion occurred within the thymus after positive selection and before NK receptor expression. Surprisingly, cytokine analysis of the developmental intermediates between NK and NK+ stages showed a T helper cell TH2 to TH1 conversion, suggesting that the regulatory functions of NK T cells may be developmentally controlled. These findings characterize novel thymic and postthymic developmental pathways that expand autoreactive cells and differentiate them into regulatory cells.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD1,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD1d,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD44,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Ly,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukins,
http://linkedlifedata.com/resource/pubmed/chemical/Klrb1c protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
19
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pubmed:volume |
296
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
553-5
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11968185-Animals,
pubmed-meshheading:11968185-Antigens,
pubmed-meshheading:11968185-Antigens, CD1,
pubmed-meshheading:11968185-Antigens, CD1d,
pubmed-meshheading:11968185-Antigens, CD44,
pubmed-meshheading:11968185-Antigens, Ly,
pubmed-meshheading:11968185-Antigens, Surface,
pubmed-meshheading:11968185-Cell Differentiation,
pubmed-meshheading:11968185-Cell Division,
pubmed-meshheading:11968185-Cell Lineage,
pubmed-meshheading:11968185-Interferon-gamma,
pubmed-meshheading:11968185-Interleukins,
pubmed-meshheading:11968185-Killer Cells, Natural,
pubmed-meshheading:11968185-Lectins, C-Type,
pubmed-meshheading:11968185-Liver,
pubmed-meshheading:11968185-Lymphocyte Activation,
pubmed-meshheading:11968185-Mice,
pubmed-meshheading:11968185-NK Cell Lectin-Like Receptor Subfamily B,
pubmed-meshheading:11968185-Proteins,
pubmed-meshheading:11968185-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:11968185-Receptors, Immunologic,
pubmed-meshheading:11968185-Spleen,
pubmed-meshheading:11968185-T-Lymphocyte Subsets,
pubmed-meshheading:11968185-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:11968185-Thymus Gland
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pubmed:year |
2002
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pubmed:articleTitle |
A thymic precursor to the NK T cell lineage.
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pubmed:affiliation |
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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