Linked Life Data

11966855

Source:http://linkedlifedata.com/resource/pubmed/id/11966855

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2002-4-22
pubmed:abstractText
Idiotypic vaccination has proven successful in several animal models and human trials. Here we suggest that the expression of cross-reactive idiotypes on factor VIII (FVIII) inhibitors of patients with haemophilia A, patients with anti-FVIII autoimmune disease and natural anti-FVIII antibodies of healthy individuals, together with the ability of anti-idiotypic reagents to neutralize anti-FVIII antibodies, provides a rationale for designing a vaccine strategy aimed at preventing the occurrence of or suppressing inhibitors, based on the induction of protective anti-idiotypes. Here we discuss the rationale supporting the concept of using idiotypic vaccination to prevent the occurrence of FVIII inhibitors in patients with haemophilia A.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1351-8216
pubmed:author
pubmed:issnType
Print
pubmed:volume
8 Suppl 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
55-9
pubmed:dateRevised
2009-10-21
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
The concept of idiotypic vaccination against factor VIII inhibitors in haemophilia A.
pubmed:affiliation
INSERM U 430 and Université Pierre et Marie Curie, Hôpital Broussais, Paris, France.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't