Linked Life Data

11964749

Source:http://linkedlifedata.com/resource/pubmed/id/11964749

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-4-19
pubmed:abstractText
Airway hyperresponsiveness remains a defining characteristic of asthma. Traditional views assert that airway smooth muscle is an important structural effector cell in the bronchi that modulates bronchomotor tone induced by contractile agonists. New evidence, however, suggests that abnormalities in airway smooth muscle functions, induced by variety of extracellular stimuli, may play an important role in the development of airway hyperresponsiveness. Studies using isolated bronchial preparations or cultured cells show that inflammatory mediators and cytokines may alter calcium homeostasis in airway smooth muscle and render the cells nonspecifically hyperreactive to agonists.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1528-4050
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
39-45
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Modulation of calcium homeostasis as a mechanism for altering smooth muscle responsiveness in asthma.
pubmed:affiliation
Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, 848 BRB II/III, 421 Curie Boulevard, Philadelphia, PA 19104, USA. amrani@mail.med.upenn.edu
pubmed:publicationType
Journal Article, Review