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rdf:type |
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lifeskim:mentions |
umls-concept:C0020663,
umls-concept:C0023810,
umls-concept:C0028128,
umls-concept:C0032016,
umls-concept:C0033268,
umls-concept:C0033559,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0083381,
umls-concept:C0205263,
umls-concept:C0282774,
umls-concept:C1280500
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pubmed:issue |
5
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pubmed:dateCreated |
2002-4-19
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pubmed:abstractText |
Injection of bacterial lipopolysaccharide (LPS) into male rats activates genes that in turn induce many enzymes that participate in the animals' response to LPS. There is induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) in many tissues. This induction could result from combination with cell surface LPS receptors that directly induce both genes, or the nitric oxide (NO) released as a result of iNOS induction could induce COX-2.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Guanidines,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazines,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/meloxicam,
http://linkedlifedata.com/resource/pubmed/chemical/pimagedine
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pubmed:status |
MEDLINE
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pubmed:issn |
1021-7401
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2002 S. Karger AG, Basel
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
276-85
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11964522-Animals,
pubmed-meshheading:11964522-Cyclooxygenase 2,
pubmed-meshheading:11964522-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:11964522-Cyclooxygenase Inhibitors,
pubmed-meshheading:11964522-Dinoprostone,
pubmed-meshheading:11964522-Endotoxemia,
pubmed-meshheading:11964522-Guanidines,
pubmed-meshheading:11964522-Hypothalamus,
pubmed-meshheading:11964522-Inflammation,
pubmed-meshheading:11964522-Isoenzymes,
pubmed-meshheading:11964522-Lipopolysaccharides,
pubmed-meshheading:11964522-Male,
pubmed-meshheading:11964522-Nitric Oxide,
pubmed-meshheading:11964522-Nitric Oxide Synthase,
pubmed-meshheading:11964522-Pituitary Gland, Anterior,
pubmed-meshheading:11964522-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:11964522-Rats,
pubmed-meshheading:11964522-Rats, Sprague-Dawley,
pubmed-meshheading:11964522-Thiazines,
pubmed-meshheading:11964522-Thiazoles,
pubmed-meshheading:11964522-Time Factors,
pubmed-meshheading:11964522-Up-Regulation
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pubmed:year |
2001
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pubmed:articleTitle |
Effects of aminoguanidine and meloxicam on nitric oxide and prostaglandin E production induced by lipopolysaccharide in the hypothalamus and anterior pituitary of the rat.
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pubmed:affiliation |
Centro de Estudios Farmacológicos y Botánicos, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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