Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2002-5-6
pubmed:abstractText
SHP (short heterodimer partner, NROB2) is an atypical orphan member of the mammalian nuclear receptor family that consists only of a putative ligand-binding domain and thus cannot bind DNA. Instead, SHP acts as a transcriptional coregulator by inhibiting the activity of various nuclear receptors (downstream targets) via occupation of the coactivator-binding surface and active repression. However, repression mechanisms have remained elusive and may involve coinhibitory factors (upstream targets) distinct from known nuclear receptor corepressors. Here, we describe the isolation of mouse E1A-like inhibitor of differentiation 1 (EID1) as a candidate coinhibitor for SHP. We characterize the interactions between SHP and EID1 and identify two repression-defective SHP mutations that have lost the ability to bind EID1. We suggest histone acetyltransferases and histones as targets for EID1 action and propose that SHP inhibition of transcription involves EID1 antagonism of CBP/p300-dependent coactivator functions.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-10097092, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-10454563, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-10490106, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-10594021, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-10648597, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-10652267, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-10681503, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-11027331, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-11030331, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-11030332, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-11073989, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-11073990, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-11136233, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-11158331, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-11163245, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-11223246, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-8521508, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-8548460, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-8650544, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-9303316, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-9372944, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-9415399, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-9430642, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-9742117, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-9773978, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-9867849, http://linkedlifedata.com/resource/pubmed/commentcorrection/11964378-9885572
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Acetyltransferases, http://linkedlifedata.com/resource/pubmed/chemical/Adenovirus E1A Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/EID1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Histones, http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides..., http://linkedlifedata.com/resource/pubmed/chemical/NCOA6 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Ncoa6 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Coactivators, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear, http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins, http://linkedlifedata.com/resource/pubmed/chemical/nuclear receptor subfamily 0...
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1469-221X
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
478-84
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:11964378-Acetyltransferases, pubmed-meshheading:11964378-Adenovirus E1A Proteins, pubmed-meshheading:11964378-Amino Acid Sequence, pubmed-meshheading:11964378-Animals, pubmed-meshheading:11964378-COS Cells, pubmed-meshheading:11964378-Carrier Proteins, pubmed-meshheading:11964378-DNA Mutational Analysis, pubmed-meshheading:11964378-Gene Expression Regulation, pubmed-meshheading:11964378-Histones, pubmed-meshheading:11964378-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:11964378-Mice, pubmed-meshheading:11964378-Molecular Sequence Data, pubmed-meshheading:11964378-Mutation, pubmed-meshheading:11964378-Nuclear Proteins, pubmed-meshheading:11964378-Nuclear Receptor Coactivators, pubmed-meshheading:11964378-Receptors, Cytoplasmic and Nuclear, pubmed-meshheading:11964378-Repressor Proteins, pubmed-meshheading:11964378-Sequence Analysis, Protein, pubmed-meshheading:11964378-Transcription, Genetic, pubmed-meshheading:11964378-Two-Hybrid System Techniques
pubmed:year
2002
pubmed:articleTitle
A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP.
pubmed:affiliation
Department of Biosciences at Novum, Karolinska Institutet, S-14157 Huddinge, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't