Linked Life Data

11962246

Source:http://linkedlifedata.com/resource/pubmed/id/11962246

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-4-18
pubmed:abstractText
Weight loss in advanced cancer patients is refractory to conventional nutritional support. This may be due to metabolic changes mediated by proinflammatory cytokines, hormones, and tumor-derived products. We previously showed that a nutritional supplement enriched with fish oil will reverse weight loss in patients with pancreatic cancer cachexia. The present study examines the effect of this supplement on a number of mediators thought to play a role in cancer cachexia. Twenty weight-losing patients with pancreatic cancer were asked to consume a nutritional supplement providing 600 kcal and 2 g of eicosapentaenoic acid per day. At baseline and after 3 wk, patients were weighed and samples were collected to measure serum concentrations of interleukin (IL)-6 and its soluble receptor tumor necrosis factor receptors I and II, cortisol, insulin, and leptin, peripheral blood mononuclear cell production of IL-1 beta, IL-6, and tumor necrosis factor, and urinary excretion of proteolysis inducing factor. After 3 wk of consumption of the fish oil-enriched nutritional supplement, there was a significant fall in production of IL-6 (from median 16.5 to 13.7 ng/ml, P = 0.015), a rise in serum insulin concentration (from 3.3 to 5.0 mU/l, P = 0.0064), a fall in the cortisol-to-insulin ratio (P = 0.0084), and a fall in the proportion of patients excreting proteolysis inducing factor (from 88% to 40%, P = 0.008). These changes occurred in association with weight gain (median 1 kg, P = 0.024). Various mediators of catabolism in cachexia are modulated by administration of a fish oil-enriched nutritional supplement in pancreatic cancer patients. This may account for the reversal of weight loss in patients consuming this supplement.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0163-5581
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
118-24
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:11962246-Adolescent, pubmed-meshheading:11962246-Adult, pubmed-meshheading:11962246-Aged, pubmed-meshheading:11962246-Blood Proteins, pubmed-meshheading:11962246-Cachexia, pubmed-meshheading:11962246-Dietary Supplements, pubmed-meshheading:11962246-Eicosapentaenoic Acid, pubmed-meshheading:11962246-Energy Intake, pubmed-meshheading:11962246-Female, pubmed-meshheading:11962246-Fish Oils, pubmed-meshheading:11962246-Humans, pubmed-meshheading:11962246-Hydrocortisone, pubmed-meshheading:11962246-Insulin, pubmed-meshheading:11962246-Interleukin-6, pubmed-meshheading:11962246-Leukocytes, Mononuclear, pubmed-meshheading:11962246-Lipopolysaccharides, pubmed-meshheading:11962246-Male, pubmed-meshheading:11962246-Middle Aged, pubmed-meshheading:11962246-Neoplasm Staging, pubmed-meshheading:11962246-Pancreatic Neoplasms, pubmed-meshheading:11962246-Proteoglycans
pubmed:year
2001
pubmed:articleTitle
Effect of a fish oil-enriched nutritional supplement on metabolic mediators in patients with pancreatic cancer cachexia.
pubmed:affiliation
University Department of Surgery, Royal Infirmary of Edinburgh, Edinburgh EH3 9YW, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't