rdf:type |
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lifeskim:mentions |
|
pubmed:issue |
4
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pubmed:dateCreated |
2002-4-18
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pubmed:abstractText |
Transforming growth factor-beta1 (TGF-beta1) has been implicated in the development of progressive nephrosclerosis in the remnant kidney model of chronic renal insufficiency. Thrombospondin-1 (TSP-1) is an extracellular matrix protein which has been recently shown to be capable of converting TGF-beta from its latent to its active form. We studied the expression of TSP-1 mRNA and protein during the development of glomerular and tubulointerstitial nephrosclerosis in the renal ablation model particularly in relation to TGF-beta1 expression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Apr
|
pubmed:issn |
0028-2766
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2002 S. Karger AG, Basel
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pubmed:issnType |
Print
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
460-70
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11961406-Animals,
pubmed-meshheading:11961406-Disease Models, Animal,
pubmed-meshheading:11961406-Fibrosis,
pubmed-meshheading:11961406-In Situ Hybridization,
pubmed-meshheading:11961406-Kidney Glomerulus,
pubmed-meshheading:11961406-Kidney Tubules,
pubmed-meshheading:11961406-Male,
pubmed-meshheading:11961406-Nephrosclerosis,
pubmed-meshheading:11961406-Platelet-Derived Growth Factor,
pubmed-meshheading:11961406-Rats,
pubmed-meshheading:11961406-Rats, Sprague-Dawley,
pubmed-meshheading:11961406-Thrombospondin 1,
pubmed-meshheading:11961406-Transforming Growth Factor beta
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pubmed:year |
2002
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pubmed:articleTitle |
Sustained expression of thrombospondin-1 is associated with the development of glomerular and tubulointerstitial fibrosis in the remnant kidney model.
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pubmed:affiliation |
Medizinische Klinik IV, Universität Erlangen-Nürnberg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|