| pubmed-article:11960700 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11960700 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11960700 | lifeskim:mentions | umls-concept:C0017189 | lld:lifeskim |
| pubmed-article:11960700 | lifeskim:mentions | umls-concept:C1519988 | lld:lifeskim |
| pubmed-article:11960700 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:11960700 | lifeskim:mentions | umls-concept:C0061132 | lld:lifeskim |
| pubmed-article:11960700 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:11960700 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:11960700 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:11960700 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11960700 | pubmed:dateCreated | 2002-4-18 | lld:pubmed |
| pubmed-article:11960700 | pubmed:abstractText | Recent studies have shown that aberrantly expressed gastrin-releasing peptide (GRP) and its receptor (GRP-R) critically regulate tumor cell differentiation in colon cancers developing in humans and mice. This finding suggested that the ability of GRP/GRP-R to promote a well-differentiated phenotype in colon cancer might reflect a re-capitulation of a normal role in regulating intestinal organogenesis. To determine if this was the case, we compared and contrasted intestinal development in GRPR-/- mice with their wild type littermates. GRP/GRP-R co-expression in wild type mice was only observed in villous enterocytes between N-1 and N-12. During this time frame villous growth was completely attenuated in GRPR-/- mice. The contribution of GRP/GRP-R to villous growth was due to their act in increasing enterocyte proliferation prior to N-8 but increasing enterocyte size thereafter. From N-12 onwards, small intestinal villous growth in GRPR-/- mice resumed such that no difference in this structure could be detected at adulthood between mice of either genotype. We next studied GRP/GRP-R expression in human abortuses. These proteins were co-expressed by villous enterocytes only between weeks 14 and 20 post-conception, a time frame analogous to when they are expressed in the murine intestine. Thus, this study shows for the first time that GRP/GRP-R play a transient and non-critical role in intestinal development, yet provides a rationale for their re-appearance in colon cancer. | lld:pubmed |
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| pubmed-article:11960700 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11960700 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11960700 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11960700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11960700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11960700 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11960700 | pubmed:month | May | lld:pubmed |
| pubmed-article:11960700 | pubmed:issn | 0925-4773 | lld:pubmed |
| pubmed-article:11960700 | pubmed:author | pubmed-author:CarrollRobert... | lld:pubmed |
| pubmed-article:11960700 | pubmed:author | pubmed-author:MatkowskyjKri... | lld:pubmed |
| pubmed-article:11960700 | pubmed:author | pubmed-author:Saunthararaja... | lld:pubmed |
| pubmed-article:11960700 | pubmed:author | pubmed-author:SekosanMarinM | lld:pubmed |
| pubmed-article:11960700 | pubmed:author | pubmed-author:BatteyJames... | lld:pubmed |
| pubmed-article:11960700 | pubmed:author | pubmed-author:BenyaRichard... | lld:pubmed |
| pubmed-article:11960700 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11960700 | pubmed:volume | 113 | lld:pubmed |
| pubmed-article:11960700 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11960700 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11960700 | pubmed:pagination | 121-30 | lld:pubmed |
| pubmed-article:11960700 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11960700 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11960700 | pubmed:articleTitle | Contribution of gastrin-releasing peptide and its receptor to villus development in the murine and human gastrointestinal tract. | lld:pubmed |
| pubmed-article:11960700 | pubmed:affiliation | Department of Medicine, University of Illinois at Chicago and Chicago Veterans Administration Medical Center (West Side Division), 840 South Wood Street (M/C 787), Chicago, IL 60612, USA. | lld:pubmed |
| pubmed-article:11960700 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11960700 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11960700 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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