Source:http://linkedlifedata.com/resource/pubmed/id/11960700
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2002-4-18
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pubmed:abstractText |
Recent studies have shown that aberrantly expressed gastrin-releasing peptide (GRP) and its receptor (GRP-R) critically regulate tumor cell differentiation in colon cancers developing in humans and mice. This finding suggested that the ability of GRP/GRP-R to promote a well-differentiated phenotype in colon cancer might reflect a re-capitulation of a normal role in regulating intestinal organogenesis. To determine if this was the case, we compared and contrasted intestinal development in GRPR-/- mice with their wild type littermates. GRP/GRP-R co-expression in wild type mice was only observed in villous enterocytes between N-1 and N-12. During this time frame villous growth was completely attenuated in GRPR-/- mice. The contribution of GRP/GRP-R to villous growth was due to their act in increasing enterocyte proliferation prior to N-8 but increasing enterocyte size thereafter. From N-12 onwards, small intestinal villous growth in GRPR-/- mice resumed such that no difference in this structure could be detected at adulthood between mice of either genotype. We next studied GRP/GRP-R expression in human abortuses. These proteins were co-expressed by villous enterocytes only between weeks 14 and 20 post-conception, a time frame analogous to when they are expressed in the murine intestine. Thus, this study shows for the first time that GRP/GRP-R play a transient and non-critical role in intestinal development, yet provides a rationale for their re-appearance in colon cancer.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0925-4773
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
113
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
121-30
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11960700-Aborted Fetus,
pubmed-meshheading:11960700-Animals,
pubmed-meshheading:11960700-Cell Division,
pubmed-meshheading:11960700-Cell Separation,
pubmed-meshheading:11960700-Digestive System,
pubmed-meshheading:11960700-Enterocytes,
pubmed-meshheading:11960700-Flow Cytometry,
pubmed-meshheading:11960700-Gastrin-Releasing Peptide,
pubmed-meshheading:11960700-Genotype,
pubmed-meshheading:11960700-Humans,
pubmed-meshheading:11960700-Immunohistochemistry,
pubmed-meshheading:11960700-Mice,
pubmed-meshheading:11960700-Phenotype,
pubmed-meshheading:11960700-Receptors, Bombesin,
pubmed-meshheading:11960700-Time Factors
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pubmed:year |
2002
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pubmed:articleTitle |
Contribution of gastrin-releasing peptide and its receptor to villus development in the murine and human gastrointestinal tract.
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pubmed:affiliation |
Department of Medicine, University of Illinois at Chicago and Chicago Veterans Administration Medical Center (West Side Division), 840 South Wood Street (M/C 787), Chicago, IL 60612, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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