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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2002-4-18
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pubmed:abstractText |
Fractalkine (FKN), also known as neurotactin, is a CX(3)C chemokine that exists in both secreted and neuronal membrane-bound forms and is upregulated during brain inflammation. There is accumulating evidence that FKN induces chemotaxis by binding to its receptor CX(3)CR1 on leukocytes and microglia. We generated FKN-deficient mice to study the role of FKN in postischemic brain injury. After transient focal cerebral ischemia, FKN-deficient mice had a 28% reduction in infarction size and lower mortality rate, when compared to wild-type littermates. The findings of this study indicate a possible role for FKN in augmenting postischemic injury and mortality after transient focal cerebral ischemia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0165-5728
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pubmed:author |
pubmed-author:AmaravadiLakshmi SLS,
pubmed-author:DunmoreJudy HJH,
pubmed-author:Fairchild-HuntressVictoriaV,
pubmed-author:FangQingQ,
pubmed-author:HuszarDennisD,
pubmed-author:PanYangY,
pubmed-author:SorianoSulpicio GSG,
pubmed-author:TonraJames RJR,
pubmed-author:WangYanming FYF,
pubmed-author:YuGary XGX,
pubmed-author:ZhouHongH
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pubmed:issnType |
Print
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pubmed:volume |
125
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
59-65
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11960641-Animals,
pubmed-meshheading:11960641-Chemokine CX3CL1,
pubmed-meshheading:11960641-Chemokines, CX3C,
pubmed-meshheading:11960641-Disease Susceptibility,
pubmed-meshheading:11960641-Gene Expression,
pubmed-meshheading:11960641-Infarction, Middle Cerebral Artery,
pubmed-meshheading:11960641-Ischemic Attack, Transient,
pubmed-meshheading:11960641-Membrane Proteins,
pubmed-meshheading:11960641-Mice,
pubmed-meshheading:11960641-Mice, Inbred BALB C,
pubmed-meshheading:11960641-Mice, Knockout,
pubmed-meshheading:11960641-RNA, Messenger,
pubmed-meshheading:11960641-Reperfusion Injury
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pubmed:year |
2002
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pubmed:articleTitle |
Mice deficient in fractalkine are less susceptible to cerebral ischemia-reperfusion injury.
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pubmed:affiliation |
Department of Anesthesia, Children's Hospital, Boston, 300 Longwood Avenue, Boston, MA 02115, USA. sulpicio.soriano@tch.harvard.edu
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pubmed:publicationType |
Journal Article
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