Linked Life Data

11960356

Source:http://linkedlifedata.com/resource/pubmed/id/11960356

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pubmed-article:11960356pubmed:abstractTextAccumulating evidence suggests that lack of balance between proliferation and apoptosis may lead to clonal expansion and cancer emergence. In diffuse large B cell lymphoma (DLBCL), survivin expression by tumor cells has been recently described as a poor prognostic marker. We assessed the relationship between survivin gene up-regulation and several other factors involved in either cell cycle or apoptosis control. The expression of 34 genes from 27 cases of DLBCL with typical IPI factor-related poor prognostic outcome was analyzed by RNase protection assay. Using non-neoplastic tissues and low grade lymphomas as control, survivin expression was high in 80% of the cases without significant relation to patient overall survival (P = 0.64). However, the expression of several genes encoding for cell cycle inhibitors, cyclins, Bcl-2 or IAP family factors was significantly associated with the survivin up-regulation. Gene expression profiling showed that both survivin and cyclin B expression can define two subgroups of DLBCL: the previously described germinal center-like and activated B-like lymphomas, determined by protein expression analysis. We also identified a preferential survivin-cyclin B relationship (P = 0.017), suggesting that cyclin B over-expression, when linked to survivin over-expression in aggressive forms of lymphoma, might demonstrate a specific G2/M transition promotion.lld:pubmed
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pubmed-article:11960356pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:11960356pubmed:articleTitleRelationship between expression of genes involved in cell cycle control and apoptosis in diffuse large B cell lymphoma: a preferential survivin-cyclin B link.lld:pubmed
pubmed-article:11960356pubmed:affiliationInstitut d'Etude et de Transfert de Gènes (IETG), Centre Hospitalier Régional et Universitaire, Hôpital Jean Minjoz, Besançon, France.lld:pubmed
pubmed-article:11960356pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11960356pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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