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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0079731,
umls-concept:C0162638,
umls-concept:C0185117,
umls-concept:C0205219,
umls-concept:C0208973,
umls-concept:C0439849,
umls-concept:C1155872,
umls-concept:C1314939,
umls-concept:C1517892,
umls-concept:C1704666,
umls-concept:C2911684
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pubmed:issue |
4
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pubmed:dateCreated |
2002-4-17
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pubmed:abstractText |
Accumulating evidence suggests that lack of balance between proliferation and apoptosis may lead to clonal expansion and cancer emergence. In diffuse large B cell lymphoma (DLBCL), survivin expression by tumor cells has been recently described as a poor prognostic marker. We assessed the relationship between survivin gene up-regulation and several other factors involved in either cell cycle or apoptosis control. The expression of 34 genes from 27 cases of DLBCL with typical IPI factor-related poor prognostic outcome was analyzed by RNase protection assay. Using non-neoplastic tissues and low grade lymphomas as control, survivin expression was high in 80% of the cases without significant relation to patient overall survival (P = 0.64). However, the expression of several genes encoding for cell cycle inhibitors, cyclins, Bcl-2 or IAP family factors was significantly associated with the survivin up-regulation. Gene expression profiling showed that both survivin and cyclin B expression can define two subgroups of DLBCL: the previously described germinal center-like and activated B-like lymphomas, determined by protein expression analysis. We also identified a preferential survivin-cyclin B relationship (P = 0.017), suggesting that cyclin B over-expression, when linked to survivin over-expression in aggressive forms of lymphoma, might demonstrate a specific G2/M transition promotion.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BIRC5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chromosomal Proteins, Non-Histone,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin B,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins,
http://linkedlifedata.com/resource/pubmed/chemical/Inhibitor of Apoptosis Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Microtubule-Associated Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonuclease, Pancreatic
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0887-6924
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
726-35
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11960356-Adolescent,
pubmed-meshheading:11960356-Adult,
pubmed-meshheading:11960356-Aged,
pubmed-meshheading:11960356-Aged, 80 and over,
pubmed-meshheading:11960356-Apoptosis,
pubmed-meshheading:11960356-Cell Cycle,
pubmed-meshheading:11960356-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:11960356-Cyclin B,
pubmed-meshheading:11960356-Cyclins,
pubmed-meshheading:11960356-Female,
pubmed-meshheading:11960356-Gene Expression,
pubmed-meshheading:11960356-Gene Expression Profiling,
pubmed-meshheading:11960356-Humans,
pubmed-meshheading:11960356-Immunoenzyme Techniques,
pubmed-meshheading:11960356-Inhibitor of Apoptosis Proteins,
pubmed-meshheading:11960356-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:11960356-Male,
pubmed-meshheading:11960356-Microtubule-Associated Proteins,
pubmed-meshheading:11960356-Middle Aged,
pubmed-meshheading:11960356-Neoplasm Proteins,
pubmed-meshheading:11960356-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:11960356-RNA, Messenger,
pubmed-meshheading:11960356-RNA, Neoplasm,
pubmed-meshheading:11960356-Ribonuclease, Pancreatic
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pubmed:year |
2002
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pubmed:articleTitle |
Relationship between expression of genes involved in cell cycle control and apoptosis in diffuse large B cell lymphoma: a preferential survivin-cyclin B link.
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pubmed:affiliation |
Institut d'Etude et de Transfert de Gènes (IETG), Centre Hospitalier Régional et Universitaire, Hôpital Jean Minjoz, Besançon, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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