Source:http://linkedlifedata.com/resource/pubmed/id/11960266
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2002-4-17
|
| pubmed:abstractText |
Biological consequences and physical complaints were compared for donors randomly assigned either to blood stem cell (BSC) or bone marrow (BM) donation. In the period 1994-1999, 61 consecutive donors were included. The BSC donors were given G-CSF 10 microg/kg s.c., daily during 5 days before the first leukapheresis. Nineteen donors had one leukapheresis, 10 required two and one donor needed three leukaphereses in order to reach the target cell number of 2 x 10(6) CD34(+) cells/kg bw of the recipient. A median platelet nadir of 102 x 10(9)/l was reached shortly after the last leukapheresis. Three weeks post harvest, 17 of 30 BSC donors had a mild leukopenia. Six had a leukopenia lasting more than a year before returning to normal values. Both groups were monitored prospectively through a standardised questionnaire completed by the donors. BSC donation was significantly less burdensome than BM donation and was preferred by the donors. The short-term risks of BSC mobilisation and harvest seem negligible. The potential long-term effects of G-CSF are unresolved and the donors must be followed closely.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0268-3369
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
479-86
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:11960266-Adolescent,
pubmed-meshheading:11960266-Adult,
pubmed-meshheading:11960266-Blood Cell Count,
pubmed-meshheading:11960266-Drug Administration Schedule,
pubmed-meshheading:11960266-Female,
pubmed-meshheading:11960266-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:11960266-Hematopoietic Stem Cell Mobilization,
pubmed-meshheading:11960266-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:11960266-Hematopoietic Stem Cells,
pubmed-meshheading:11960266-Humans,
pubmed-meshheading:11960266-Leukapheresis,
pubmed-meshheading:11960266-Leukopenia,
pubmed-meshheading:11960266-Living Donors,
pubmed-meshheading:11960266-Male,
pubmed-meshheading:11960266-Middle Aged,
pubmed-meshheading:11960266-Prospective Studies,
pubmed-meshheading:11960266-Questionnaires,
pubmed-meshheading:11960266-Tissue and Organ Harvesting
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Donation of stem cells from blood or bone marrow: results of a randomised study of safety and complaints.
|
| pubmed:affiliation |
Medical Department, Rikshospitalet University Hospital, 0027 Oslo, Norway.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|