Linked Life Data

11959656

Source:http://linkedlifedata.com/resource/pubmed/id/11959656

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2002-4-17
pubmed:abstractText
The reason for sex differences in arrhythmic risk remains unclear. Heterogeneity of ventricular repolarization is directly linked to arrhythmogenesis; thus we investigated repolarization homogeneity and its circadian pattern in men and women. During 24-h Holter recordings in 60 healthy subjects (27 males), a 12-lead electrocardiogram (ECG) was obtained every 30 s. RR and QT intervals, and, after singular-value decomposition, two characteristics of repolarization homogeneity were calculated in each ECG. Corrected QT (QTc) values were obtained using an individually optimized heart rate (HR) correction formula. All values were averaged over 10-min time bands from 0000 to 2400. There were substantial sex differences in both global repolarization homogeneity (measured by the total cosine of the angle between QRS and T wave vectors) and regional homogeneity of repolarization (quantified independently by the relative T wave residuum). Whereas women throughout the 24 h followed more closely the pattern of inverse sequence between depolarization and repolarization, they also showed much higher localized repolarization heterogeneity than men. In both women and men, repolarization irregularity was greatest during morning hours. A sex difference was also observed for HR and QTc interval; however, the circadian patterns of the repolarization homogeneity descriptors were different from those of HR and QTc intervals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0363-6135
pubmed:author
pubmed:issnType
Print
pubmed:volume
282
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
H1889-97
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Sex differences in repolarization homogeneity and its circadian pattern.
pubmed:affiliation
Department of Cardiological Sciences, St. George's Hospital Medical School, London SW17 0RE, United Kingdom.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't