rdf:type |
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lifeskim:mentions |
|
pubmed:issue |
5
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pubmed:dateCreated |
2002-4-17
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pubmed:abstractText |
Nucleotide-dependent unblocking of chain-terminated DNA by human immunodeficiency virus type 1 reverse transcriptase (RT) is enhanced by the presence of mutations associated with 3'-azido-3'-deoxythymidine (AZT) resistance. The increase in unblocking activity was greater for mutant combinations associated with higher levels of in vivo AZT resistance. The difference between mutant and wild-type activity was further enhanced by introduction of a methyl group into the nucleotide substrate and was decreased for a nonaromatic substrate, suggesting that pi-pi interactions between RT and an aromatic structure may be facilitated by these mutations.
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pubmed:grant |
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-10445025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-11083661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-11312355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-11435603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-1377403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-1694849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-1699273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-1720152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-2340178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-2430286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-2434477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-2449866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-2479733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-7509370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-7509634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-7512165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-7513745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-7532306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-7682554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-7687065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-7693703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-9033399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-9420060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-9603976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-9689112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-9811824,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-9843396
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pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0066-4804
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
46
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1540-5
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pubmed:dateRevised |
2010-9-29
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pubmed:meshHeading |
pubmed-meshheading:11959594-Antiviral Agents,
pubmed-meshheading:11959594-DNA Primers,
pubmed-meshheading:11959594-Dinucleoside Phosphates,
pubmed-meshheading:11959594-Drug Resistance, Viral,
pubmed-meshheading:11959594-HIV Reverse Transcriptase,
pubmed-meshheading:11959594-HIV-1,
pubmed-meshheading:11959594-Models, Molecular,
pubmed-meshheading:11959594-Mutation,
pubmed-meshheading:11959594-Nucleotides,
pubmed-meshheading:11959594-Reverse Transcriptase Inhibitors,
pubmed-meshheading:11959594-Substrate Specificity,
pubmed-meshheading:11959594-Templates, Genetic,
pubmed-meshheading:11959594-Zidovudine
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pubmed:year |
2002
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pubmed:articleTitle |
Effects of specific zidovudine resistance mutations and substrate structure on nucleotide-dependent primer unblocking by human immunodeficiency virus type 1 reverse transcriptase.
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pubmed:affiliation |
Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, Florida 33101, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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