Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2002-4-17
pubmed:abstractText
Nucleotide-dependent unblocking of chain-terminated DNA by human immunodeficiency virus type 1 reverse transcriptase (RT) is enhanced by the presence of mutations associated with 3'-azido-3'-deoxythymidine (AZT) resistance. The increase in unblocking activity was greater for mutant combinations associated with higher levels of in vivo AZT resistance. The difference between mutant and wild-type activity was further enhanced by introduction of a methyl group into the nucleotide substrate and was decreased for a nonaromatic substrate, suggesting that pi-pi interactions between RT and an aromatic structure may be facilitated by these mutations.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-10445025, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-11083661, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-11312355, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-11435603, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-1377403, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-1694849, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-1699273, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-1720152, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-2340178, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-2430286, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-2434477, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-2449866, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-2479733, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-7509370, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-7509634, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-7512165, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-7513745, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-7532306, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-7682554, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-7687065, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-7693703, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-9033399, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-9420060, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-9603976, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-9689112, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-9811824, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-9831551, http://linkedlifedata.com/resource/pubmed/commentcorrection/11959594-9843396
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1540-5
pubmed:dateRevised
2010-9-29
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Effects of specific zidovudine resistance mutations and substrate structure on nucleotide-dependent primer unblocking by human immunodeficiency virus type 1 reverse transcriptase.
pubmed:affiliation
Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, Florida 33101, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.