Linked Life Data

11959054

Source:http://linkedlifedata.com/resource/pubmed/id/11959054

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2002-4-17
pubmed:abstractText
Some patients with chronic asthma develop irreversible airflow obstruction. Our aim was to assess whether reported duration of asthma and induced sputum cell counts were associated with pulmonary function in patients with asthma who did not smoke. Maximal forced expiratory volume in the first second (FEV(1)) was determined following a steroid trial (oral prednisolone, 30 mg/d [n = 92 patients]; or inhaled fluticasone, 2000 microg/d [n = 5]; for 2 weeks) and 2.5 mg of nebulized albuterol. Asthma history was recorded with duration from first diagnosis. All subjects were nonsmokers, or were to have stopped smoking > or =5 years previously and smoked < or =5 pack-years (n = 12). Induced sputum was obtained from 59 subjects for analysis of airway cell counts. Maximal FEV(1) was inversely associated with asthma duration (r = -0.47, P <0.0001), age (r = -0.40, P <0.0001), and the proportion of sputum neutrophils (r(s) = -0.50, P = 0.00004). After adjusting for age, both duration of disease and sputum neutrophils were independently associated with maximal FEV(1). Neutrophil activation, as measured by sputum myeloperoxidase levels, was positively associated with the proportion of sputum neutrophils (r(s) = 0.45, P = 0.0004) and inversely associated with maximal FEV(1) (r(s) = -0.59, P <0.0001). Long disease duration may be a predisposing factor for the development of irreversible airflow obstruction in patients with chronic asthma. The negative associations of sputum neutrophil count and activation with maximal FEV(1) suggest that neutrophils may be involved in the pathophysiology of irreversible airflow obstruction in asthma.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0002-9343
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
112
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
446-52
pubmed:dateRevised
2009-11-3
pubmed:meshHeading
pubmed-meshheading:11959054-Administration, Topical, pubmed-meshheading:11959054-Adult, pubmed-meshheading:11959054-Albuterol, pubmed-meshheading:11959054-Androstadienes, pubmed-meshheading:11959054-Anti-Inflammatory Agents, pubmed-meshheading:11959054-Asthma, pubmed-meshheading:11959054-Bronchodilator Agents, pubmed-meshheading:11959054-Chronic Disease, pubmed-meshheading:11959054-Clinical Trials as Topic, pubmed-meshheading:11959054-Female, pubmed-meshheading:11959054-Forced Expiratory Volume, pubmed-meshheading:11959054-Glucocorticoids, pubmed-meshheading:11959054-Humans, pubmed-meshheading:11959054-Leukocyte Count, pubmed-meshheading:11959054-Linear Models, pubmed-meshheading:11959054-Male, pubmed-meshheading:11959054-Middle Aged, pubmed-meshheading:11959054-Neutrophils, pubmed-meshheading:11959054-Prednisolone, pubmed-meshheading:11959054-Spirometry, pubmed-meshheading:11959054-Sputum, pubmed-meshheading:11959054-Time Factors
pubmed:year
2002
pubmed:articleTitle
Association of forced expiratory volume with disease duration and sputum neutrophils in chronic asthma.
pubmed:affiliation
Department of Respiratory Medicine, University of Glasgow, Glasgow, Scotland, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't