Source:http://linkedlifedata.com/resource/pubmed/id/11959005
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2002-4-17
|
| pubmed:abstractText |
A series of novel N-[1-(1-substituted 4-piperidinylmethyl)-4-piperidinyl]benzamides was prepared and its compounds were evaluated for their binding to 5-HT(4) receptors and effects on gastrointestinal motility in conscious dogs. 4-Amino-N-[1-[1-(4-aminobutyl)-4-piperidinylmethyl]-4-piperidinyl]-5-chloro-2-methoxybenzamide (15) was found to have a potent binding affinity for 5-HT(4) receptors (IC(50): 6.47nM) and showed excellent colonic prokinetic activity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
25
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
967-70
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:11959005-Animals,
pubmed-meshheading:11959005-Benzamides,
pubmed-meshheading:11959005-Digestive System,
pubmed-meshheading:11959005-Dogs,
pubmed-meshheading:11959005-Gastrointestinal Agents,
pubmed-meshheading:11959005-Protein Binding,
pubmed-meshheading:11959005-Serotonin,
pubmed-meshheading:11959005-Serotonin Receptor Agonists,
pubmed-meshheading:11959005-Structure-Activity Relationship
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Novel N-[1-(1-substituted 4-piperidinylmethyl)-4-piperidinyl]benzamides as potent colonic prokinetic agents.
|
| pubmed:affiliation |
Medicinal Chemistry Group, Chemistry Research Laboratories, Dainippon Pharmaceutical Co., Ltd., Enoki 33-94, Osaka 564-0053, Suita, Japan.
|
| pubmed:publicationType |
Journal Article
|