Source:http://linkedlifedata.com/resource/pubmed/id/11958993
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2002-4-17
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| pubmed:abstractText |
Synthesis and structure-activity relationship (SAR) studies of L-cysteine-based N-type calcium channel blockers are described. In the course of exploring SAR of the N- and C-terminal substituents, the L-cysteine derivative was found to be a potent N-type calcium channel blocker with an IC(50) value of 0.14 microM on IMR-32 assay. Compound showed 12-fold selectivity for N-type over L-type calcium channels on AtT-20 assay.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0960-894X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
25
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
915-8
|
| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11958993-Calcium Channel Blockers,
pubmed-meshheading:11958993-Calcium Channels, N-Type,
pubmed-meshheading:11958993-Cysteine,
pubmed-meshheading:11958993-Humans,
pubmed-meshheading:11958993-Inhibitory Concentration 50,
pubmed-meshheading:11958993-Structure-Activity Relationship,
pubmed-meshheading:11958993-Tumor Cells, Cultured,
pubmed-meshheading:11958993-omega-Conotoxins
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Structure-activity study of L-cysteine-based N-type calcium channel blockers: optimization of N- and C-terminal substituents.
|
| pubmed:affiliation |
Minase Research Institute, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto, Mishima, 618-8585, Osaka, Japan. seko@ono.co.jp
|
| pubmed:publicationType |
Journal Article
|