Source:http://linkedlifedata.com/resource/pubmed/id/11958836
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2002-4-17
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| pubmed:abstractText |
Effect of nicotine on nitric oxide synthase (NOS) expression in various hypothalamic regions was investigated in rats via nicotineamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry. Sprague-Dawley rats were divided into the fed group, the fed and nicotine-treated group, the food-deprived group, and the food-deprived and nicotine-treated group. The fed groups received abundant food and water, while food was withheld from the food-deprived groups for 48 h. The nicotine-treated groups were injected with nicotine. Following food deprivation, enhanced NAPDH-d expression was detected in the paraventricular nucleus, ventromedial hypothalamic nucleus, and lateral hypothalamic area of the hypothalamus. Nicotine administration to the food-deprived rats resulted in decreased NADPH-d positivity. The present results indicate that nicotine administration is effective in limiting the enhancement in NOS expression following food restriction.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0304-3940
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
29
|
| pubmed:volume |
322
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
29-32
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11958836-Animals,
pubmed-meshheading:11958836-Appetite Regulation,
pubmed-meshheading:11958836-Food Deprivation,
pubmed-meshheading:11958836-Hypothalamic Area, Lateral,
pubmed-meshheading:11958836-Hypothalamus,
pubmed-meshheading:11958836-Immunohistochemistry,
pubmed-meshheading:11958836-Male,
pubmed-meshheading:11958836-NADPH Dehydrogenase,
pubmed-meshheading:11958836-Nicotine,
pubmed-meshheading:11958836-Nitrergic Neurons,
pubmed-meshheading:11958836-Nitric Oxide,
pubmed-meshheading:11958836-Nitric Oxide Synthase,
pubmed-meshheading:11958836-Obesity,
pubmed-meshheading:11958836-Paraventricular Hypothalamic Nucleus,
pubmed-meshheading:11958836-Rats,
pubmed-meshheading:11958836-Rats, Sprague-Dawley,
pubmed-meshheading:11958836-Tobacco Use Disorder,
pubmed-meshheading:11958836-Up-Regulation,
pubmed-meshheading:11958836-Ventromedial Hypothalamic Nucleus
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Nicotine administration decreases nitric oxide synthase expression in the hypothalamus of food-deprived rats.
|
| pubmed:affiliation |
Department of Physiology, College of Medicine, Kyung Hee University, 1 Hoigi-dong, Dongdaemun-gu, Seoul 130-701, South Korea.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|