Linked Life Data

11957784

Source:http://linkedlifedata.com/resource/pubmed/id/11957784

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2002-4-17
pubmed:abstractText
Organophosphorous pesticides exert sensitizing effects. Our investigations in workers of the chlorfenvinphos production department showed frequent incidence of the upper respiratory tract allergy as well as diminished specific airways conductance. The aim of the study is to assess serum immunoglobulin E concentration in the workers of the chemical plant department producing chlorfenvinphos. The study covered the entire staff of the department:--35 men aged 25-55 years, employed for 1-15 years. Chronic bronchitis was diagnosed in 13 (37.1%) workers; in none of the subjects examined bronchial asthma was found. Spirometry showed a lower Tiffeneau's index in 5 (14.3%) and impaired specific airways conductance in 11 (31.4%) workers. Air chlorfenvinphos concentration in the work environment did not exceed MAC level, the average concentration was 0.0008-0.0018 mg/m3, and the erythrocyte acetylcholinesterase activity was within normal range. Serum IgE concentration was evaluated with the enzyme immunoassay (Enzymun-Test IgE from Boehringer, Cat. No. 1289071), the results were compared with those of a control group of 30 healthy male inhabitants of the region, professionally not exposed to chemical noxes. Mean serum IgE concentration in the workers (109.6 +/- 120.0 IU/ml) was significantly (p < 0.01) higher as compared to the control group (51.1 +/- 36.4 IU/ml). In 14 (40.0%) workers the IgE concentration exceeded 100 IU/ml, whereas in the control group only in 4 (13.3%) people the IgE level was elevated. The results of our investigations provide support for an essential role of type I hypersensitivity reaction in the pathogenesis of inflammatory changes in the respiratory system caused by chlorfenvinphos.
pubmed:language
pol
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0033-2240
pubmed:author
pubmed:issnType
Print
pubmed:volume
58 Suppl 7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
49-50
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
[Serum immunoglobulin E concentration in workers producing chlorfenvinphos].
pubmed:affiliation
Klinika Chorób Wewnetrznych i Farmakologii Klinicznej Slaskiej Akademii Medycznej, ul. Medyków 14, 40-752 Katowice.
pubmed:publicationType
Journal Article, English Abstract