Source:http://linkedlifedata.com/resource/pubmed/id/11957154
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2002-4-16
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| pubmed:abstractText |
Hepatosplenic gammadelta-T-cell lymphoma (HSTCL) is a rare extranodal T-cell non-Hodgkin's lymphoma (T-NHL) with only 46 well-documented cases in medical literature. Notably, a relatively high number of these case reports (15%) describe the occurrence of HSTCL after solid organ transplantation. We describe the case of a 45-year-old man who developed a leukemic HSTCL 5 years after renal transplantation and continous immunosuppression with cyclosporine A and prednisolone. After a rapid clinical course, the patient died and autopsy was performed. The malignant lymphocytes showed a natural killer-like gammadelta-T-cell phenotype (CD2(+), CD3(+), CD7(+), TCR gammadelta(+), CD56(+), TIA-1(+), CD4(-), CD8(-), and TCR alphabeta(-)) and infiltrated the sinusoids of liver and the red pulp of the spleen. Cytogenetically, an isochromosome 7q, trisomy 8, Y-loss, and a translocation t(1;4) was detectable. This case shows the difficulties of recognizing HSTCL early in the clinical course and underlines that all types of T-NHL, nodal as well as extranodal, have to be considered in the differential diagnosis of posttransplantation lymphoproliferative disorders. Moreover, HSTCL seems to occur as a specific late complication of solid organ transplantation.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
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| pubmed:issn |
0046-8177
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2002, Elsevier Science (USA). All rights reserved.
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| pubmed:issnType |
Print
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| pubmed:volume |
33
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
253-8
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11957154-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:11957154-Cadaver,
pubmed-meshheading:11957154-Chromosomes, Human, Pair 7,
pubmed-meshheading:11957154-Fatal Outcome,
pubmed-meshheading:11957154-Flow Cytometry,
pubmed-meshheading:11957154-Humans,
pubmed-meshheading:11957154-Immunophenotyping,
pubmed-meshheading:11957154-Isochromosomes,
pubmed-meshheading:11957154-Karyotyping,
pubmed-meshheading:11957154-Kidney Transplantation,
pubmed-meshheading:11957154-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:11957154-Liver Neoplasms,
pubmed-meshheading:11957154-Lymphoma, T-Cell,
pubmed-meshheading:11957154-Male,
pubmed-meshheading:11957154-Middle Aged,
pubmed-meshheading:11957154-Polymerase Chain Reaction,
pubmed-meshheading:11957154-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:11957154-Splenic Neoplasms
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Hepatosplenic gammadelta-T-cell lymphoma with leukemic course after renal transplantation.
|
| pubmed:affiliation |
Division of Haematology and Oncology, University Hospital Innsbruck, Austria.
|
| pubmed:publicationType |
Journal Article,
Case Reports
|