Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-4-16
pubmed:abstractText
Human gut wall cytochrome P(450) (CYP)3A4 is inhibited by grapefruit juice (G), whereas smoking increases CYP1A2 activity. Both enzymes contribute to verapamil biotransformation. This study was performed to quantitatively assess the effect of these factors on verapamil pharmacokinetics in steady state.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/6 beta-hydroxycortisol, http://linkedlifedata.com/resource/pubmed/chemical/CYP3A protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP1A2, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A, http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System, http://linkedlifedata.com/resource/pubmed/chemical/Flavanones, http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids, http://linkedlifedata.com/resource/pubmed/chemical/Hydrocortisone, http://linkedlifedata.com/resource/pubmed/chemical/Mixed Function Oxygenases, http://linkedlifedata.com/resource/pubmed/chemical/Verapamil, http://linkedlifedata.com/resource/pubmed/chemical/naringenin
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0031-6970
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
45-53
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:11956673-Adult, pubmed-meshheading:11956673-Beverages, pubmed-meshheading:11956673-Calcium Channel Blockers, pubmed-meshheading:11956673-Chromatography, High Pressure Liquid, pubmed-meshheading:11956673-Citrus, pubmed-meshheading:11956673-Cross-Over Studies, pubmed-meshheading:11956673-Cytochrome P-450 CYP1A2, pubmed-meshheading:11956673-Cytochrome P-450 CYP3A, pubmed-meshheading:11956673-Cytochrome P-450 Enzyme System, pubmed-meshheading:11956673-Female, pubmed-meshheading:11956673-Flavanones, pubmed-meshheading:11956673-Flavonoids, pubmed-meshheading:11956673-Food-Drug Interactions, pubmed-meshheading:11956673-Humans, pubmed-meshheading:11956673-Hydrocortisone, pubmed-meshheading:11956673-Male, pubmed-meshheading:11956673-Mixed Function Oxygenases, pubmed-meshheading:11956673-Smoking, pubmed-meshheading:11956673-Stereoisomerism, pubmed-meshheading:11956673-Verapamil
pubmed:year
2002
pubmed:articleTitle
Effects of grapefruit juice and smoking on verapamil concentrations in steady state.
pubmed:affiliation
Institute for Pharmacology, Clinical Pharmacology, University of Köln, Germany. uwe.fuhr@medizin.uni-koeln.de
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't