rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-4-16
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pubmed:abstractText |
Human gut wall cytochrome P(450) (CYP)3A4 is inhibited by grapefruit juice (G), whereas smoking increases CYP1A2 activity. Both enzymes contribute to verapamil biotransformation. This study was performed to quantitatively assess the effect of these factors on verapamil pharmacokinetics in steady state.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/6 beta-hydroxycortisol,
http://linkedlifedata.com/resource/pubmed/chemical/CYP3A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP1A2,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/Flavanones,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrocortisone,
http://linkedlifedata.com/resource/pubmed/chemical/Mixed Function Oxygenases,
http://linkedlifedata.com/resource/pubmed/chemical/Verapamil,
http://linkedlifedata.com/resource/pubmed/chemical/naringenin
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0031-6970
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
45-53
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11956673-Adult,
pubmed-meshheading:11956673-Beverages,
pubmed-meshheading:11956673-Calcium Channel Blockers,
pubmed-meshheading:11956673-Chromatography, High Pressure Liquid,
pubmed-meshheading:11956673-Citrus,
pubmed-meshheading:11956673-Cross-Over Studies,
pubmed-meshheading:11956673-Cytochrome P-450 CYP1A2,
pubmed-meshheading:11956673-Cytochrome P-450 CYP3A,
pubmed-meshheading:11956673-Cytochrome P-450 Enzyme System,
pubmed-meshheading:11956673-Female,
pubmed-meshheading:11956673-Flavanones,
pubmed-meshheading:11956673-Flavonoids,
pubmed-meshheading:11956673-Food-Drug Interactions,
pubmed-meshheading:11956673-Humans,
pubmed-meshheading:11956673-Hydrocortisone,
pubmed-meshheading:11956673-Male,
pubmed-meshheading:11956673-Mixed Function Oxygenases,
pubmed-meshheading:11956673-Smoking,
pubmed-meshheading:11956673-Stereoisomerism,
pubmed-meshheading:11956673-Verapamil
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pubmed:year |
2002
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pubmed:articleTitle |
Effects of grapefruit juice and smoking on verapamil concentrations in steady state.
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pubmed:affiliation |
Institute for Pharmacology, Clinical Pharmacology, University of Köln, Germany. uwe.fuhr@medizin.uni-koeln.de
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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