Source:http://linkedlifedata.com/resource/pubmed/id/11956052
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
2002-4-16
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pubmed:abstractText |
Critical illness outcome may be causally related to inflammatory response severity. Given that tissue angiotensin-converting-enzyme (ACE) regulates such responses and that the deletion (D) [rather than insertion (I)] variant of the ACE gene is associated with higher tissue ACE levels, DD genotype might be associated with a poorer outcome in a uniform infectious disease state. Illness severity (Pediatric RIsk of Mortality score, the Glasgow Meningococcal Septicaemia Prognostic Score [GMSPS], and clinical course) was recorded for consecutive white patients with meningococcal disease (n = 110, 34 DD genotype, 61 male, aged 49.4 +/- 5.4 months) referred to the Royal Liverpool Children's Hospital, UK. Compared with children with > or = I allele, DD genotype was associated with 14% higher predicted risk of mortality (p = 0.038), higher GMSPS (DD 9.4 +/- 0.5, ID/II 7.7+/- 0.4 [mean +/- SEM], p = 0.013), greater prevalence of inotropic support (76% versus 55%, p = 0.03) and ventilation (82% versus 63%, p = 0.04), and longer Pediatric Intensive Care Unit (PICU) stay (5.8 versus 3.9, p = 0.02). DD genotype frequency was 6% (1 case) for the 18 children who did not require PICU care, 33% for the 84 PICU survivors, and 45% for those who died (p = 0.01). ACE DD is associated with increased illness severity in meningococcal disease.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1073-449X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
165
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1103-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11956052-Base Sequence,
pubmed-meshheading:11956052-Child, Preschool,
pubmed-meshheading:11956052-DNA Transposable Elements,
pubmed-meshheading:11956052-Female,
pubmed-meshheading:11956052-Genotype,
pubmed-meshheading:11956052-Humans,
pubmed-meshheading:11956052-Male,
pubmed-meshheading:11956052-Meningococcal Infections,
pubmed-meshheading:11956052-Peptidyl-Dipeptidase A,
pubmed-meshheading:11956052-Polymorphism, Genetic,
pubmed-meshheading:11956052-Prognosis,
pubmed-meshheading:11956052-Risk Factors,
pubmed-meshheading:11956052-Sequence Deletion,
pubmed-meshheading:11956052-Survival Rate
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pubmed:year |
2002
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pubmed:articleTitle |
Severity of meningococcal disease in children and the angiotensin-converting enzyme insertion/deletion polymorphism.
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pubmed:affiliation |
Peter Dunn Neonatal Intensive Care Unit and Department of Child Health, University of Bristol, Bristol, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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