Source:http://linkedlifedata.com/resource/pubmed/id/11956051
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2002-4-16
|
| pubmed:abstractText |
Persistent pulmonary hypertension secondary to meconium aspiration syndrome is an important cause of morbidity and mortality in the neonatal population. We investigated the use of the phosphodiesterase-5 inhibitor sildenafil, in its intravenous form, as a pulmonary vasodilator in a model of meconium aspiration syndrome. Pulmonary hypertension was induced in 18 piglets, by endotracheal instillation of human meconium, 6 piglets subsequently received an infusion of intravenous sildenafil for 2 hours, 6 received inhaled nitric oxide for 2 hours, and 6 control animals received no additional intervention. Meconium aspiration increased pulmonary vascular resistance by 70%, and increased oxygenation index by over 100%. Pulmonary vascular resistance remained elevated for the remainder of the study period in control animals. Inhaled nitric oxide reduced the pulmonary vascular resistance by 40% after 2 hours of treatment; intravenous sildenafil completely reversed the increase in pulmonary vascular resistance within 1 hour of commencing the infusion. Neither agent had an effect on systemic hemodynamics. Sildenafil also increased cardiac output by 30%, but while doing so did not adversely influence oxygenation. Intravenous sildenafil is a selective and highly effective pulmonary vasodilator, which is at least as effective as inhaled nitric oxide, in this model of neonatal persistent pulmonary hypertension.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphodiesterase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Purines,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfones,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents,
http://linkedlifedata.com/resource/pubmed/chemical/sildenafil
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1073-449X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
165
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1098-102
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:11956051-Administration, Inhalation,
pubmed-meshheading:11956051-Animals,
pubmed-meshheading:11956051-Hemodynamics,
pubmed-meshheading:11956051-Humans,
pubmed-meshheading:11956051-Infant, Newborn,
pubmed-meshheading:11956051-Infusions, Intravenous,
pubmed-meshheading:11956051-Meconium Aspiration Syndrome,
pubmed-meshheading:11956051-Nitric Oxide,
pubmed-meshheading:11956051-Persistent Fetal Circulation Syndrome,
pubmed-meshheading:11956051-Phosphodiesterase Inhibitors,
pubmed-meshheading:11956051-Piperazines,
pubmed-meshheading:11956051-Pulmonary Circulation,
pubmed-meshheading:11956051-Pulmonary Wedge Pressure,
pubmed-meshheading:11956051-Purines,
pubmed-meshheading:11956051-Sulfones,
pubmed-meshheading:11956051-Swine,
pubmed-meshheading:11956051-Vascular Resistance,
pubmed-meshheading:11956051-Vasodilator Agents
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Intravenous sildenafil lowers pulmonary vascular resistance in a model of neonatal pulmonary hypertension.
|
| pubmed:affiliation |
Department of Cardiac Intensive Care, Great Ormond Street Hospital, London, United Kingdom. shekel@cryptic.rch.unimelb.edu.au
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|