Linked Life Data

11954871

Source:http://linkedlifedata.com/resource/pubmed/id/11954871

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-4-16
pubmed:abstractText
The idiopathic inflammatory myopathies (IIM) are a heterogeneous group of systemic diseases that include the familiar disease entities of dermatomyositis (DM), polymyositis (PM), and inclusion body myositis (IBM). A subset of patients has unique autoantibodies which are specific for IIM (myositis specific autoantibodies; MSAs). We studied the clinical and serological characteristics of IIM in 125 Dutch patients. Sera were analysed by immunoblotting, enzyme-linked immunosorbent assay, and immunoprecipitation. The most frequently encountered MSA was the anti-Jo-1 autoantibody (20%), followed by anti-tRNAHis (6%), anti-Mi-2 (6%), and anti-SRP (4%). The presence of certain MSAs was clearly associated with specific clinical characteristics. Anti-Jo-1 and anti-tRNAHis were associated with the anti-synthetase syndrome, anti-SRP with PM with severe myalgia and arthralgia and a moderate response to immunosuppressive treatment. A novel finding was the presence of anti-Mi-2, not only in DM, but also in PM. MSAs were frequently present in DM/PM sera, but were hardly ever detected in the sera of IBM patients. The few IBM patients with MSAs demonstrated a significant response to immunosuppressive treatment. It can be concluded that MSAs define specific clinical syndromes within the spectrum of IIM and that they can assist in the differential diagnosis and treatment plan of these enigmatic disorders by virtually excluding IBM by their presence, and by potentially identifying a subgroup of steroid-responsive IBM patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0340-5354
pubmed:author
pubmed:issnType
Print
pubmed:volume
249
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
69-75
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:11954871-Adenosine Triphosphatases, pubmed-meshheading:11954871-Adult, pubmed-meshheading:11954871-Autoantibodies, pubmed-meshheading:11954871-Autoantigens, pubmed-meshheading:11954871-DNA Helicases, pubmed-meshheading:11954871-Dermatomyositis, pubmed-meshheading:11954871-Female, pubmed-meshheading:11954871-Histidine-tRNA Ligase, pubmed-meshheading:11954871-Humans, pubmed-meshheading:11954871-Ligases, pubmed-meshheading:11954871-Male, pubmed-meshheading:11954871-Mi-2 Nucleosome Remodeling and Deacetylase Complex, pubmed-meshheading:11954871-Middle Aged, pubmed-meshheading:11954871-Muscle, Skeletal, pubmed-meshheading:11954871-Myositis, pubmed-meshheading:11954871-Myositis, Inclusion Body, pubmed-meshheading:11954871-Netherlands, pubmed-meshheading:11954871-Polymyositis, pubmed-meshheading:11954871-RNA, Transfer
pubmed:year
2002
pubmed:articleTitle
Clinical and serological characteristics of 125 Dutch myositis patients. Myositis specific autoantibodies aid in the differential diagnosis of the idiopathic inflammatory myopathies.
pubmed:affiliation
Neuromuscular Centre Nijmegen, Institute of Neurology, University Medical Centre Nijmegen, The Netherlands. g.hengstman@czzoneu.azn.nl
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't