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pubmed-article:11953965pubmed:abstractTextThe presence of certain HLA class II antigens is strongly associated with the progression of joint destruction in rheumatoid arthritis (RA). Such antigens may be more effective than other class II antigens in inducing the formation of autoreactive T cells after presentation of (auto)antigens. We investigated whether early and aggressive treatment with disease-modifying antirheumatic drugs could modify this relationship.lld:pubmed
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pubmed-article:11953965pubmed:articleTitleEarly and aggressive treatment of rheumatoid arthritis patients affects the association of HLA class II antigens with progression of joint damage.lld:pubmed
pubmed-article:11953965pubmed:affiliationDepartment of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands. l.r.lard@lumc.nllld:pubmed
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