rdf:type |
|
lifeskim:mentions |
umls-concept:C0001721,
umls-concept:C0003873,
umls-concept:C0004083,
umls-concept:C0022417,
umls-concept:C0030705,
umls-concept:C0087111,
umls-concept:C0312653,
umls-concept:C0449258,
umls-concept:C0580822,
umls-concept:C1547300,
umls-concept:C1548760,
umls-concept:C1550594,
umls-concept:C1883709
|
pubmed:issue |
4
|
pubmed:dateCreated |
2002-4-15
|
pubmed:abstractText |
The presence of certain HLA class II antigens is strongly associated with the progression of joint destruction in rheumatoid arthritis (RA). Such antigens may be more effective than other class II antigens in inducing the formation of autoreactive T cells after presentation of (auto)antigens. We investigated whether early and aggressive treatment with disease-modifying antirheumatic drugs could modify this relationship.
|
pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0004-3591
|
pubmed:author |
pubmed-author:BoeroAA,
pubmed-author:BreedveldF CFC,
pubmed-author:De VriesR R PRR,
pubmed-author:HazesJ M WJM,
pubmed-author:HuizingaT W JTW,
pubmed-author:ORUEJJ,
pubmed-author:SchreuderG M TGM,
pubmed-author:VerhoevenAA,
pubmed-author:VissetJJ,
pubmed-author:VosKK,
pubmed-author:ZanellaMM,
pubmed-author:ZwindermanA HAH,
pubmed-author:van der LindenSS
|
pubmed:issnType |
Print
|
pubmed:volume |
46
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
899-905
|
pubmed:dateRevised |
2004-11-17
|
pubmed:meshHeading |
pubmed-meshheading:11953965-Adult,
pubmed-meshheading:11953965-Aged,
pubmed-meshheading:11953965-Alleles,
pubmed-meshheading:11953965-Antirheumatic Agents,
pubmed-meshheading:11953965-Arthritis, Rheumatoid,
pubmed-meshheading:11953965-Disease Progression,
pubmed-meshheading:11953965-Female,
pubmed-meshheading:11953965-Genetic Predisposition to Disease,
pubmed-meshheading:11953965-Genotype,
pubmed-meshheading:11953965-Histocompatibility Antigens Class II,
pubmed-meshheading:11953965-Humans,
pubmed-meshheading:11953965-Joints,
pubmed-meshheading:11953965-Male,
pubmed-meshheading:11953965-Middle Aged,
pubmed-meshheading:11953965-Prospective Studies
|
pubmed:year |
2002
|
pubmed:articleTitle |
Early and aggressive treatment of rheumatoid arthritis patients affects the association of HLA class II antigens with progression of joint damage.
|
pubmed:affiliation |
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands. l.r.lard@lumc.nl
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|