Linked Life Data

11952875

Source:http://linkedlifedata.com/resource/pubmed/id/11952875

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2002-4-15
pubmed:abstractText
1. It has been shown that magnetic fields (MFs) affect a variety of biological effects in animal brains. There have been few experiments on the effects of MFs on sleep. Therefore, we investigated whether extremely low frequency (ELF) MFs affect the sleep induced by clonidine, a central alpha(2)-adrenoceptor agonist. Clonidine produced dose-related increase of the sleeping time and dose-related decrease of the onset time in 2-day-old chicks. 2. Exposure of chicks to MFs (5, 10, 20 G; for 3, 6, 9, 12 h) significantly increased the clonidine-induced sleep time as a direct function of intensity and duration of MF application. Clonidine reduced noradrenaline or tyrosine in the brain, an effect which was not further changed in animals exposed to MF. 3. To determine whether the gamma amino butyric acid A (GABA(A))/benzodiazepine (BZD) receptor system is involved in the decrease in clonidine-induced sleep caused by activation of central alpha(2)-adrenergic systems, we examined exposure of chicks to the effects of the BZD receptor antagonist flumazenil (0.5 mg kg(-1), i.p.) and GABA(A) antagonist bicuculline (0.1 mg kg-1, i.p.) on clonidine-induced sleep. Bicuculline and flumazenil inhibited the increase of clonidine-induced sleep time by MFs. Clonidine or MFs did not change GABA levels in the brain. 4. These results suggest that MFs can increase clonidine-induced sleep via a change of GABA(A) and BZD receptor system irrespective of the concentration of GABA or noradrenaline in the brain of 2-day-old chicks.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0144-1795
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
197-203
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:11952875-Adrenergic alpha-2 Receptor Agonists, pubmed-meshheading:11952875-Adrenergic alpha-Agonists, pubmed-meshheading:11952875-Animals, pubmed-meshheading:11952875-Animals, Newborn, pubmed-meshheading:11952875-Bicuculline, pubmed-meshheading:11952875-Brain Chemistry, pubmed-meshheading:11952875-Chickens, pubmed-meshheading:11952875-Chromatography, High Pressure Liquid, pubmed-meshheading:11952875-Clonidine, pubmed-meshheading:11952875-Dose-Response Relationship, Drug, pubmed-meshheading:11952875-Electrochemistry, pubmed-meshheading:11952875-Electromagnetic Fields, pubmed-meshheading:11952875-Flumazenil, pubmed-meshheading:11952875-GABA Antagonists, pubmed-meshheading:11952875-GABA Modulators, pubmed-meshheading:11952875-Norepinephrine, pubmed-meshheading:11952875-Sleep, pubmed-meshheading:11952875-Tyrosine, pubmed-meshheading:11952875-gamma-Aminobutyric Acid
pubmed:year
2001
pubmed:articleTitle
The influences of extremely low frequency magnetic fields on clonidine-induced sleep in 2-day-old chicks.
pubmed:affiliation
Department of Pharmacology, College of Pharmacy, Chung Ang University, Seoul 156-756, Republic of Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't