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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
25
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pubmed:dateCreated |
2002-6-17
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pubmed:abstractText |
Simultaneous deregulation of both Wnt and ErbB growth factors has previously been shown to result in the cooperative induction of mammary gland tumors. Using the murine mammary tumor virus (MMTV)-Wnt-1 transgenic model of mammary carcinoma, we have identified an unvarying association between beta-catenin and epidermal growth factor receptor/c-Neu (ErbB1/ErbB2) heterodimers in mammary gland tumors, indicating a requirement for ErbB signaling in Wnt-mediated tumorigenesis. Expansion of these observations to a second transgenic model, MMTV-c-Neu, demonstrated similar tumor-specific interactions, including an ErbB1 ligand-inducible phosphorylation of both beta-catenin and c-Neu. Direct relevance of these findings to human breast cancer was established upon examination of a set of human infiltrating ductal breast adenocarcinoma and lymph node metastasis tissues taken at surgery. These data revealed increased levels of beta-catenin in tumors and metastases versus normal breast as well as an association between beta-catenin and c-Neu that measurably occurs only in neoplasia, most strongly in metastatic lesions. These studies have identified a seemingly indispensable interaction between beta-catenin and epidermal growth factor receptor/c-Neu heterodimers in Wnt-1-mediated breast tumorigenesis that may indicate a fundamental signaling event in human metastatic progression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Catnb protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-2,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/WNT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt1 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Zebrafish Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
277
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
22692-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11950845-Adenocarcinoma,
pubmed-meshheading:11950845-Animals,
pubmed-meshheading:11950845-Breast Neoplasms,
pubmed-meshheading:11950845-Cytoskeletal Proteins,
pubmed-meshheading:11950845-Humans,
pubmed-meshheading:11950845-Immunoblotting,
pubmed-meshheading:11950845-Immunohistochemistry,
pubmed-meshheading:11950845-Ligands,
pubmed-meshheading:11950845-Mammary Tumor Virus, Mouse,
pubmed-meshheading:11950845-Mice,
pubmed-meshheading:11950845-Mice, Transgenic,
pubmed-meshheading:11950845-Microscopy, Fluorescence,
pubmed-meshheading:11950845-Phosphorylation,
pubmed-meshheading:11950845-Precipitin Tests,
pubmed-meshheading:11950845-Protein Binding,
pubmed-meshheading:11950845-Proto-Oncogene Proteins,
pubmed-meshheading:11950845-Receptor, Epidermal Growth Factor,
pubmed-meshheading:11950845-Receptor, erbB-2,
pubmed-meshheading:11950845-Signal Transduction,
pubmed-meshheading:11950845-Trans-Activators,
pubmed-meshheading:11950845-Tumor Cells, Cultured,
pubmed-meshheading:11950845-Tyrosine,
pubmed-meshheading:11950845-Wnt Proteins,
pubmed-meshheading:11950845-Wnt1 Protein,
pubmed-meshheading:11950845-Zebrafish Proteins,
pubmed-meshheading:11950845-beta Catenin
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pubmed:year |
2002
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pubmed:articleTitle |
ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas.
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pubmed:affiliation |
Tumor Biology Program and Department of Biochemistry and Molecular Biology, Mayo Medical/Graduate School, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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