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rdf:type |
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lifeskim:mentions |
umls-concept:C0005516,
umls-concept:C0027912,
umls-concept:C0149925,
umls-concept:C0242485,
umls-concept:C0337112,
umls-concept:C0392762,
umls-concept:C0443286,
umls-concept:C1332009,
umls-concept:C1524075,
umls-concept:C1555029,
umls-concept:C2348519
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pubmed:issue |
4
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pubmed:dateCreated |
2002-4-11
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pubmed:abstractText |
The Human Achaete-Scute homologue 1 (HASH1, ASCL1), a lineage-specific basic helix-loop-helix member of the achaete-scute family, is essential for the generation of pulmonary neuroendocrine (NE) cells during lung development. In small cell lung cancer (SCLC), the most lethal form of lung cancer, the gene is highly expressed and the expression of HASH1 correlates with NE features found in SCLCs. Here we describe a highly sensitive reverse transcription-PCR method for quantifying HASH1 mRNA in clinical samples, using real-time fluorescence resonance energy transfer technology (LightCycler).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ASCL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxymethylbilane Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1082-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11948117-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:11948117-Carcinoma, Neuroendocrine,
pubmed-meshheading:11948117-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:11948117-Carcinoma, Small Cell,
pubmed-meshheading:11948117-DNA-Binding Proteins,
pubmed-meshheading:11948117-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:11948117-Humans,
pubmed-meshheading:11948117-Hydroxymethylbilane Synthase,
pubmed-meshheading:11948117-Lung Neoplasms,
pubmed-meshheading:11948117-RNA, Complementary,
pubmed-meshheading:11948117-RNA, Messenger,
pubmed-meshheading:11948117-RNA, Neoplasm,
pubmed-meshheading:11948117-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11948117-Transcription Factors,
pubmed-meshheading:11948117-Tumor Cells, Cultured,
pubmed-meshheading:11948117-Tumor Markers, Biological,
pubmed-meshheading:11948117-Up-Regulation
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pubmed:year |
2002
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pubmed:articleTitle |
Quantitative reverse transcription-polymerase chain reaction measurement of HASH1 (ASCL1), a marker for small cell lung carcinomas with neuroendocrine features.
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pubmed:affiliation |
Molecular Biology Laboratory, Department of Clinical Chemistry, VU University Medical Center, 1081 HV Amsterdam, the Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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