| pubmed-article:11947893 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11947893 | lifeskim:mentions | umls-concept:C0282402 | lld:lifeskim |
| pubmed-article:11947893 | lifeskim:mentions | umls-concept:C0043210 | lld:lifeskim |
| pubmed-article:11947893 | lifeskim:mentions | umls-concept:C0080103 | lld:lifeskim |
| pubmed-article:11947893 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:11947893 | lifeskim:mentions | umls-concept:C0023824 | lld:lifeskim |
| pubmed-article:11947893 | lifeskim:mentions | umls-concept:C0201950 | lld:lifeskim |
| pubmed-article:11947893 | lifeskim:mentions | umls-concept:C0596690 | lld:lifeskim |
| pubmed-article:11947893 | lifeskim:mentions | umls-concept:C0232970 | lld:lifeskim |
| pubmed-article:11947893 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:11947893 | lifeskim:mentions | umls-concept:C0036806 | lld:lifeskim |
| pubmed-article:11947893 | lifeskim:mentions | umls-concept:C0428466 | lld:lifeskim |
| pubmed-article:11947893 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11947893 | pubmed:dateCreated | 2002-4-11 | lld:pubmed |
| pubmed-article:11947893 | pubmed:abstractText | Hepatic lipase (HL) is a lipolytic enzyme that catalyzes hydrolysis of triglycerides and phospholipids in all major classes of lipoproteins. Recently, a -514C/T polymorphism in the promoter region of the HL gene was found to be associated with variations in hepatic lipase activity and serum high density lipoprotein cholesterol (HDL-C) levels. Postmenopausal hormone replacement therapy (HRT) has known favorable effects on serum lipid and lipoprotein levels. In this study, we examined the relation between the -514C/T polymorphism and serum lipid and lipoprotein levels in postmenopausal women prior to and after 3 months of HRT. Significant associations between the -514 C/T polymorphism and HDL-C, low density lipoprotein cholesterol (LDL-C) and apolipoprotein A-I (apo A-I) levels were observed before and/or after 3 months of HRT. With HRT, serum total cholesterol (TC), LDL-C and apolipoprotein B (apo B) levels were reduced significantly (P=0.0001), and HDL-C and apo A-I levels were increased significantly (P=0.0001). However, the degrees of change in lipid and lipoprotein levels due to HRT did not differ significantly between the HL genotypes. | lld:pubmed |
| pubmed-article:11947893 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11947893 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11947893 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11947893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11947893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11947893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11947893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11947893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11947893 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11947893 | pubmed:month | May | lld:pubmed |
| pubmed-article:11947893 | pubmed:issn | 0021-9150 | lld:pubmed |
| pubmed-article:11947893 | pubmed:author | pubmed-author:Yamakawa-Koba... | lld:pubmed |
| pubmed-article:11947893 | pubmed:author | pubmed-author:ArinamiTadaoT | lld:pubmed |
| pubmed-article:11947893 | pubmed:author | pubmed-author:HamaguchiHide... | lld:pubmed |
| pubmed-article:11947893 | pubmed:author | pubmed-author:SomekawaYoshi... | lld:pubmed |
| pubmed-article:11947893 | pubmed:author | pubmed-author:TomuraShigeoS | lld:pubmed |
| pubmed-article:11947893 | pubmed:author | pubmed-author:FujimuraMitsu... | lld:pubmed |
| pubmed-article:11947893 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11947893 | pubmed:volume | 162 | lld:pubmed |
| pubmed-article:11947893 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11947893 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11947893 | pubmed:pagination | 17-21 | lld:pubmed |
| pubmed-article:11947893 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11947893 | pubmed:meshHeading | pubmed-meshheading:11947893... | lld:pubmed |
| pubmed-article:11947893 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11947893 | pubmed:articleTitle | Relation of the -514C/T polymorphism in the hepatic lipase gene to serum HDL and LDL cholesterol levels in postmenopausal women under hormone replacement therapy. | lld:pubmed |
| pubmed-article:11947893 | pubmed:affiliation | Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba 305-8575, Japan. kkimiko@md.tsukuba.ac.jp | lld:pubmed |
| pubmed-article:11947893 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11947893 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:11947893 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3990 | entrezgene:pubmed | pubmed-article:11947893 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:11947893 | lld:entrezgene |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11947893 | lld:pubmed |
