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rdf:type |
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lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0023824,
umls-concept:C0036806,
umls-concept:C0043210,
umls-concept:C0080103,
umls-concept:C0201950,
umls-concept:C0232970,
umls-concept:C0282402,
umls-concept:C0428466,
umls-concept:C0596690,
umls-concept:C1882417
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pubmed:issue |
1
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pubmed:dateCreated |
2002-4-11
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pubmed:abstractText |
Hepatic lipase (HL) is a lipolytic enzyme that catalyzes hydrolysis of triglycerides and phospholipids in all major classes of lipoproteins. Recently, a -514C/T polymorphism in the promoter region of the HL gene was found to be associated with variations in hepatic lipase activity and serum high density lipoprotein cholesterol (HDL-C) levels. Postmenopausal hormone replacement therapy (HRT) has known favorable effects on serum lipid and lipoprotein levels. In this study, we examined the relation between the -514C/T polymorphism and serum lipid and lipoprotein levels in postmenopausal women prior to and after 3 months of HRT. Significant associations between the -514 C/T polymorphism and HDL-C, low density lipoprotein cholesterol (LDL-C) and apolipoprotein A-I (apo A-I) levels were observed before and/or after 3 months of HRT. With HRT, serum total cholesterol (TC), LDL-C and apolipoprotein B (apo B) levels were reduced significantly (P=0.0001), and HDL-C and apo A-I levels were increased significantly (P=0.0001). However, the degrees of change in lipid and lipoprotein levels due to HRT did not differ significantly between the HL genotypes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein A-I,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins B,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogens, Conjugated (USP),
http://linkedlifedata.com/resource/pubmed/chemical/Lipase,
http://linkedlifedata.com/resource/pubmed/chemical/Medroxyprogesterone Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0021-9150
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
162
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
17-21
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11947893-Adult,
pubmed-meshheading:11947893-Aged,
pubmed-meshheading:11947893-Alleles,
pubmed-meshheading:11947893-Apolipoprotein A-I,
pubmed-meshheading:11947893-Apolipoproteins B,
pubmed-meshheading:11947893-Cholesterol, HDL,
pubmed-meshheading:11947893-Cholesterol, LDL,
pubmed-meshheading:11947893-Estrogen Replacement Therapy,
pubmed-meshheading:11947893-Estrogens, Conjugated (USP),
pubmed-meshheading:11947893-Female,
pubmed-meshheading:11947893-Genotype,
pubmed-meshheading:11947893-Humans,
pubmed-meshheading:11947893-Japan,
pubmed-meshheading:11947893-Lipase,
pubmed-meshheading:11947893-Liver,
pubmed-meshheading:11947893-Medroxyprogesterone Acetate,
pubmed-meshheading:11947893-Middle Aged,
pubmed-meshheading:11947893-Polymorphism, Genetic,
pubmed-meshheading:11947893-Postmenopause,
pubmed-meshheading:11947893-Treatment Outcome,
pubmed-meshheading:11947893-Triglycerides,
pubmed-meshheading:11947893-Women's Health
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pubmed:year |
2002
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pubmed:articleTitle |
Relation of the -514C/T polymorphism in the hepatic lipase gene to serum HDL and LDL cholesterol levels in postmenopausal women under hormone replacement therapy.
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pubmed:affiliation |
Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba 305-8575, Japan. kkimiko@md.tsukuba.ac.jp
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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