Linked Life Data

11938910

Source:http://linkedlifedata.com/resource/pubmed/id/11938910

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2002-4-9
pubmed:abstractText
The recognition mechanism of enantioselectivity in cyclodextrin-modified capillary zone electrophoresis (CD-CZE) on a racemic basic drug terbutaline was discussed. The equilibrium constants of host-guest complexation of terbutaline enantiomers with alpha-cyclodextrin, beta-cyclodextrin, 2,6-dimethyl-beta-cycoldextrin, 2,3,6-trimethyl-beta-cyclodextrin and 2-hydroxy-propyl-beta-cyclodextrin, and the thermodynamic parameters for chiral recognition procedure were determined respectively. It was found that the matching properties between cavity of cyclodextrins and enantiomers were interrelated with the equilibrium constants of binding complexes and selectivities(a) calculated from the ratio of binding constants of two enantiomers were in the same order of maximum electrophoretic mobility difference between two enantiomers responding with cyclodextrin additive. The experimental value of optimal concentration of cyclodextrin agreed with that calculated from the equation Copt = 1/(K1K2)1/2. From the thermodynamic parameter determination it was shown that the hydrogen-bonding interactions between terbutaline enantiomers and 2-hydroxy-propyl-beta-cyclodextrin and beta-cyclodextrin should be positive factors.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1000-8713
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
481-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
[A study on the binding of cyclodextrins with terbutaline enantiomers by chiral capilary zone electrophoresis].
pubmed:affiliation
Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000.
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't