Source:http://linkedlifedata.com/resource/pubmed/id/11937563
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2002-4-8
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| pubmed:abstractText |
Allergen provocation of allergic asthma patients is often characterized by an initial period of bronchoconstriction, or early phase reaction (EPR), that leads to maximal airway narrowing within 15-30 min, followed by a recovery period returning airway function to baseline within 1-2 h. In this study, we used a defined OVA provocation model and mice deficient for specific leukocyte populations to investigate the cellular/molecular origins of the EPR. OVA-sensitized/challenged wild-type (C57BL/6J) mice displayed an EPR following OVA provocation. However, this response was absent in gene knockout animals deficient of either B or T cells. Moreover, transfer of OVA-specific IgG, but not IgE, before the OVA provocation, was capable of inducing the EPR in both strains of lymphocyte-deficient mice. Interestingly, an EPR was also observed in sensitized/challenged mast cell-deficient mice following an OVA provocation. These data show that the EPR in the mouse is an immunologically based pathophysiological response that requires allergen-specific IgG but occurs independent of mast cell activities. Thus, in the mouse the initial period of bronchoconstriction following allergen exposure may involve neither mast cells nor IgE-mediated events.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aerosols,
http://linkedlifedata.com/resource/pubmed/chemical/Allergens,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Ovalbumin
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| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
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| pubmed:volume |
168
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
4050-4
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11937563-Administration, Inhalation,
pubmed-meshheading:11937563-Aerosols,
pubmed-meshheading:11937563-Allergens,
pubmed-meshheading:11937563-Animals,
pubmed-meshheading:11937563-Antibody Specificity,
pubmed-meshheading:11937563-B-Lymphocytes,
pubmed-meshheading:11937563-Bronchoconstriction,
pubmed-meshheading:11937563-Crosses, Genetic,
pubmed-meshheading:11937563-Immunoglobulin E,
pubmed-meshheading:11937563-Immunoglobulin G,
pubmed-meshheading:11937563-Injections, Intraperitoneal,
pubmed-meshheading:11937563-Lymphopenia,
pubmed-meshheading:11937563-Mast Cells,
pubmed-meshheading:11937563-Mice,
pubmed-meshheading:11937563-Mice, Inbred C57BL,
pubmed-meshheading:11937563-Mice, Knockout,
pubmed-meshheading:11937563-Ovalbumin,
pubmed-meshheading:11937563-T-Lymphocytes,
pubmed-meshheading:11937563-Time Factors
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| pubmed:year |
2002
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| pubmed:articleTitle |
Early phase bronchoconstriction in the mouse requires allergen-specific IgG.
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| pubmed:affiliation |
Divisions of Hematology/Oncology and Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, Scottsdale, AZ 85259, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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