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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2002-4-8
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pubmed:abstractText |
A series of 9-halo PGF analogues 1-2 and 5-13 were synthesized and biologically evaluated. Among the compounds, 2 was the best EP2-receptor agonist. A practical method of synthesizing 2 via the Julia olefination of an aldehyde 3 with an optically active sulfone 4, which was prepared by Sharpless asymmetric epoxidation of 15, was developed. Other 9-halogenated PGF analogues were synthesized essentially by the same procedure and evaluated. The absolute configuration of 16-OH of 2 was determined as S by the X-ray analysis of a salt consisting of a 1/1 molar ratio of 2 and L-lysine.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0968-0896
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pubmed:author |
pubmed-author:EgashiraHiromuH,
pubmed-author:HaradaHiroyukiH,
pubmed-author:HasegawaTomoyukiT,
pubmed-author:IshidaAkiharuA,
pubmed-author:KawanakaYasufumiY,
pubmed-author:KondoKigenK,
pubmed-author:MaruyamaTakayukiT,
pubmed-author:MiyazakiToruT,
pubmed-author:NaganawaAtsushiA,
pubmed-author:NakaiHisaoH,
pubmed-author:OdagakiYoshihikoY,
pubmed-author:OgawaMikioM,
pubmed-author:OhuchidaShuichiS,
pubmed-author:SagawaKenjiK,
pubmed-author:TaniKousukeK,
pubmed-author:TodaMasaakiM
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1883-94
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:11937346-Animals,
pubmed-meshheading:11937346-CHO Cells,
pubmed-meshheading:11937346-Cricetinae,
pubmed-meshheading:11937346-Crystallography, X-Ray,
pubmed-meshheading:11937346-Cyclic AMP,
pubmed-meshheading:11937346-Halogens,
pubmed-meshheading:11937346-Molecular Conformation,
pubmed-meshheading:11937346-Molecular Structure,
pubmed-meshheading:11937346-Prostaglandins F, Synthetic,
pubmed-meshheading:11937346-Receptors, Prostaglandin E,
pubmed-meshheading:11937346-Second Messenger Systems,
pubmed-meshheading:11937346-Structure-Activity Relationship
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pubmed:year |
2002
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pubmed:articleTitle |
A practical synthesis and biological evaluation of 9-halogenated PGF analogues.
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pubmed:affiliation |
Minase Research Institute, Ono Pharmaceutical Co., Ltd., Shimamoto, Mishima, 618-8585, Osaka, Japan. k.tani@ono.co.jp
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pubmed:publicationType |
Journal Article
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