|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
2002-4-8
|
|
pubmed:abstractText |
There is a growing interest in low-dose ketamine as an analgesic agent in different intractable pain conditions. Due to its narrow therapeutic window, well-defined pharmacokinetic parameters are essential for its successful use in these situations. Arterial data for ketamine or its enantiomers have not been reported before. The metabolic pathways involved in the metabolism of S- and R-ketamines are not known.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0031-6970
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
57
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
869-75
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:11936706-Adult,
pubmed-meshheading:11936706-Area Under Curve,
pubmed-meshheading:11936706-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:11936706-Cognition,
pubmed-meshheading:11936706-Cytochrome P-450 CYP2D6,
pubmed-meshheading:11936706-Cytochrome P-450 Enzyme System,
pubmed-meshheading:11936706-Hemodynamics,
pubmed-meshheading:11936706-Humans,
pubmed-meshheading:11936706-Ketamine,
pubmed-meshheading:11936706-Male,
pubmed-meshheading:11936706-Middle Aged,
pubmed-meshheading:11936706-Mixed Function Oxygenases,
pubmed-meshheading:11936706-Stereoisomerism
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Pharmacokinetics and non-analgesic effects of S- and R-ketamines in healthy volunteers with normal and reduced metabolic capacity.
|
|
pubmed:affiliation |
Division of Anaesthesiology and Intensive Care, Karolinska Institutet, Huddinge University Hospital, Sweden. jan.persson@anaesth.hs.sll.se
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
