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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-4-8
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pubmed:abstractText |
This review focuses on the product of the pallidin (Pldn) gene, one of a number of genes that in mice are associated with pigmentation defects and platelet dense granule deficiency. A similar combination of defects is also observed in patients suffering from Hermansky-Pudlak (HPS) and Chediak-Higashi (CHS) syndromes. Pldn encodes a novel, approximately 20-kDa protein that is expressed ubiquitously in mammalian tissues. The pallidin protein was found to bind to syntaxin 13, a member of the syntaxin family of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). As SNARE proteins mediate fusion of intracellular membranes, pallidin may play a role in membrane fusion events required for melanosome biogenesis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0893-5785
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
82-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11936273-Alternative Splicing,
pubmed-meshheading:11936273-Animals,
pubmed-meshheading:11936273-Carrier Proteins,
pubmed-meshheading:11936273-Gene Expression,
pubmed-meshheading:11936273-Humans,
pubmed-meshheading:11936273-Lectins,
pubmed-meshheading:11936273-Melanosomes,
pubmed-meshheading:11936273-Membrane Proteins,
pubmed-meshheading:11936273-Mice,
pubmed-meshheading:11936273-Mice, Mutant Strains,
pubmed-meshheading:11936273-Qa-SNARE Proteins,
pubmed-meshheading:11936273-SNARE Proteins,
pubmed-meshheading:11936273-Vesicular Transport Proteins
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pubmed:year |
2002
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pubmed:articleTitle |
The pallidin (Pldn) gene and the role of SNARE proteins in melanosome biogenesis.
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pubmed:affiliation |
Department of Human Genetics, University of California at Los Angeles (UCLA) School of Medicine, 90095, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review
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