Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1492
pubmed:dateCreated
2002-4-5
pubmed:abstractText
The breeding system of parasitic protozoa affects the evolution of drug resistance and virulence, and is relevant to disease diagnosis and the development of chemo- and immunotherapy. A major group of protozoan parasites, the phylum Apicomplexa, that includes the aetiological agents of malaria, toxoplasmosis and coccidiosis, all have dimorphic sexual stages. The sex ratio (proportion of males produced by parasites) is predicted to depend upon the inbreeding rate, and it has been suggested that sex-ratio data offer a relatively cheap and easy method for indirectly estimating inbreeding rates. Here, we exploit a new theoretical machinery to show that there are generally valid relationships between f, Wright's coefficient of inbreeding, and sex ratio, z(*), the generality being with respect to population structure. To focus the discussion, we concentrate on malaria and show that the previously derived result, f = 1 - 2z(*), does not depend on the artificial assumptions about population structure that were previously made. Not only does this justify the use of sex ratio as an indirect measure of f, but also we argue that it may actually be preferable to measure f by measuring sex ratios, rather than by measuring departures from Hardy-Weinberg genotypic proportions both in malaria and parasites more generally.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11934369-10714880, http://linkedlifedata.com/resource/pubmed/commentcorrection/11934369-10893865, http://linkedlifedata.com/resource/pubmed/commentcorrection/11934369-11034827, http://linkedlifedata.com/resource/pubmed/commentcorrection/11934369-11206546, http://linkedlifedata.com/resource/pubmed/commentcorrection/11934369-11872397, http://linkedlifedata.com/resource/pubmed/commentcorrection/11934369-1355855, http://linkedlifedata.com/resource/pubmed/commentcorrection/11934369-15275150, http://linkedlifedata.com/resource/pubmed/commentcorrection/11934369-1641238, http://linkedlifedata.com/resource/pubmed/commentcorrection/11934369-17040751, http://linkedlifedata.com/resource/pubmed/commentcorrection/11934369-2320563, http://linkedlifedata.com/resource/pubmed/commentcorrection/11934369-3738836, http://linkedlifedata.com/resource/pubmed/commentcorrection/11934369-6021675, http://linkedlifedata.com/resource/pubmed/commentcorrection/11934369-7218818, http://linkedlifedata.com/resource/pubmed/commentcorrection/11934369-7569897, http://linkedlifedata.com/resource/pubmed/commentcorrection/11934369-7630901, http://linkedlifedata.com/resource/pubmed/commentcorrection/11934369-7750746, http://linkedlifedata.com/resource/pubmed/commentcorrection/11934369-8501926, http://linkedlifedata.com/resource/pubmed/commentcorrection/11934369-8763356, http://linkedlifedata.com/resource/pubmed/commentcorrection/11934369-9288818
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0962-8452
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
269
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
755-60
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Inbreeding and parasite sex ratios.
pubmed:affiliation
Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK. sean.nee@ed.ac.uk
pubmed:publicationType
Journal Article