|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:dateCreated |
2002-4-4
|
|
pubmed:abstractText |
The effects of perilla (Perilla frutescens, Labiatae) on murine cultured vascular smooth muscle cells (VSMC) were investigated. The water extract of perilla leaves induced nitric oxide (NO) production of VSMC and this effect was synergistically augmented when combined with interferon (IFN)-gamma or tumour necrosis factor (TNF)-alpha, while the perilla extract significantly inhibited NO production induced by IFN-gamma combined with lipopolysaccharide (LPS). Northern blot analysis revealed that these effects of the perilla extract paralleled mRNA expression of inducible nitric oxide synthase. However, the perilla extract significantly inhibited platelet derived growth factor (PDGF) or TNF-alpha-induced VSMC proliferation measured as DNA synthesis. The inhibitory effect of the perilla extract on TNF-alpha-induced VSMC proliferation was significantly suppressed by N(G)-monomethyl-L-arginine, a non-specific nitric synthase inhibitor, suggesting that this effect was partially mediated by NO production as an autocrine/paracrine factor. The present findings suggest that perilla would be useful for the prevention of vascular diseases such as arteriosclerosis.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/NOS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0951-418X
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 2002 John Wiley & Sons, Ltd.
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
16 Suppl 1
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
S19-23
|
|
pubmed:dateRevised |
2011-10-27
|
|
pubmed:meshHeading |
pubmed-meshheading:11933134-Animals,
pubmed-meshheading:11933134-Aorta,
pubmed-meshheading:11933134-Arteriosclerosis,
pubmed-meshheading:11933134-Blotting, Northern,
pubmed-meshheading:11933134-Cells, Cultured,
pubmed-meshheading:11933134-DNA Replication,
pubmed-meshheading:11933134-Female,
pubmed-meshheading:11933134-Humans,
pubmed-meshheading:11933134-Interferon-gamma,
pubmed-meshheading:11933134-Lamiaceae,
pubmed-meshheading:11933134-Mice,
pubmed-meshheading:11933134-Mice, Inbred BALB C,
pubmed-meshheading:11933134-Muscle, Smooth, Vascular,
pubmed-meshheading:11933134-Nitric Oxide,
pubmed-meshheading:11933134-Nitric Oxide Synthase,
pubmed-meshheading:11933134-Nitric Oxide Synthase Type II,
pubmed-meshheading:11933134-Phytotherapy,
pubmed-meshheading:11933134-Plant Extracts,
pubmed-meshheading:11933134-RNA, Messenger,
pubmed-meshheading:11933134-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Effect of Perilla frutescens on nitric oxide production and DNA synthesis in cultured murine vascular smooth muscle cells.
|
|
pubmed:affiliation |
Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
|
|
pubmed:publicationType |
Journal Article
|
