Linked Life Data

11930155

Source:http://linkedlifedata.com/resource/pubmed/id/11930155

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2002-4-3
pubmed:databankReference
pubmed:abstractText
Hypothalamic orexin-containing neurons project to many CNS targets, including motoneurons. We assessed developmental changes in the expression of the orexin type 2 receptor (ORX2r) mRNA in hypoglossal (XII) motoneurons. Identified motoneurons were dissociated from 4- to 33-day-old rats and subjected to single-cell reverse transcription and PCR; nearly all contained the ORX2r mRNA. In 40 motoneurons studied using semi-nested PCR, and in another 39 subjected to quantitative, real-time PCR, the number of reverse-transcribed mRNA copies per cell was significantly higher around day 20 postnatally than at any other age. Thus, ORX may postsynaptically excite XII motoneurons, with the ORX2r mRNA production increased during the critical period for development of the rapid eye movement sleep and its disorder narcolepsy/cataplexy.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
433-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Developmental changes in the orexin 2 receptor mRNA in hypoglossal motoneurons.
pubmed:affiliation
Department of Animal Biology, School of Veterinary Medicine and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104-6046, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.