Linked Life Data

11928840

Source:http://linkedlifedata.com/resource/pubmed/id/11928840

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-4-3
pubmed:abstractText
Herpes zoster (HZ) is induced by diseases or medical treatments leading to a decrease in cell-mediated immunity, but in most cases it appears without any detectable, predisposing condition. We report here that susceptibility to HZ is genetically determined. The promoter region of the IL-10 gene contains 3 single-nucleotide polymorphisms (G/A at -1082, C/T at -819 and C/A at -592) which form 3 haplotypes, GCC, ACC and ATA. These haplotypes are known to differ in terms of their effect on the transcription of the IL-10 gene. In a cohort of 60 HZV patients, the number of carriers of the ATA haplotype was 32 (53%), while in blood donors the frequency was 151/400 (38%) (p < 0.05).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0036-5548
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
112-4
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Polymorphism of the IL-10 gene is associated with susceptibility to herpes zoster.
pubmed:affiliation
Department of Neurology and Rehabilitation, Tampere University Hospital, Finland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't