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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
2002-4-2
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pubmed:abstractText |
The functional changes associated with cellular senescence may be involved in human aging and age-related vascular disorders. We have shown the important role of telomere and telomerase in vascular cell senescence in vitro. Progressive telomere shortening in vivo has been observed in the regions susceptible to atherosclerosis, implying contributions to atherogenesis. However, whether senescent vascular cells are present in the vasculature and contribute to the pathogenesis of atherosclerosis remains unclear.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
2
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1541-4
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11927518-Cell Aging,
pubmed-meshheading:11927518-Cells, Cultured,
pubmed-meshheading:11927518-Coronary Artery Disease,
pubmed-meshheading:11927518-Coronary Vessels,
pubmed-meshheading:11927518-Endothelium, Vascular,
pubmed-meshheading:11927518-Humans,
pubmed-meshheading:11927518-Intercellular Adhesion Molecule-1,
pubmed-meshheading:11927518-Nitric Oxide Synthase,
pubmed-meshheading:11927518-Nitric Oxide Synthase Type III,
pubmed-meshheading:11927518-Telomerase,
pubmed-meshheading:11927518-Telomere,
pubmed-meshheading:11927518-beta-Galactosidase
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pubmed:year |
2002
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pubmed:articleTitle |
Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction.
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pubmed:affiliation |
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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