Linked Life Data

11926412

Source:http://linkedlifedata.com/resource/pubmed/id/11926412

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-4-2
pubmed:abstractText
Death receptors are a subgroup of TNF-receptor family members that can trigger caspase-8 activation and apoptosis upon interaction with their selective ligands. One of the death receptors, Fas (CD95) and its ligand is critically involved in the regulation of immune homeostasis and effectorfunction. Fas-mediated cell death is a major pathway of cytolytic T-cell-mediated death that is involved in specific killing of tumor cells. Recent investigations summarized herein have shown that defective Fas-signaling due to receptor downregulation or dysfunction, or intracellular inhibition by FLIP (FLICE inhibitory protein) can interfere with Fas-mediated tumor cell death, and thereby favor tumor immune escape.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1044-579X
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
51-5
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Defective death receptor signaling as a cause of tumor immune escape.
pubmed:affiliation
Department of Dermatology, Geneva University Hospital, Switzerland.
pubmed:publicationType
Journal Article, Review