Source:http://linkedlifedata.com/resource/pubmed/id/11924123
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2002-4-1
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pubmed:abstractText |
The multicomponent VP-4 vaccine from Klebsiella pneumonia, Staphyloccocus aureus, Proteus vulgaris, Escherichia coli antigens was used to prevent acute respiratory diseases (ARD) at preschoolchildren's establishments. Prevention was effected during an influenza epidemic with a drastic rise in the incidence of ARD. The VP-4 use involved 3 nasal and 6-9 oral administrations of the drug at an interval of 3-4 days. The duration of the course was 26 +/- 4 days. The preventive action of VP-4 on the incidence of ARD was followed up for 14 months after vaccination. One group comprised 89 vaccinated children, a matched group included 69 children whose age was 2 to 6 years. Immunoprophylaxis was found to promote a reduction in the number of children who had 4 ARD episodes or more during the whole follow-up. Administration of VP-4 prevented the development of repeated episodes ARD in a group of children aged 2-3 years and in frequently ill children who had 3 infections or more in the previous year. The slight reactogenicity of the drug and its long-term preventive effect allow this method of immunoprophylaxis to be recommended for frequently ill children, for those at high risk, and for those in the junior age group (under 4 years) before going to preschoolchildren's establishments.
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pubmed:language |
rus
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0869-6047
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
29-30
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11924123-Bacterial Vaccines,
pubmed-meshheading:11924123-Child,
pubmed-meshheading:11924123-Child, Preschool,
pubmed-meshheading:11924123-Humans,
pubmed-meshheading:11924123-Incidence,
pubmed-meshheading:11924123-Respiratory Tract Infections,
pubmed-meshheading:11924123-School Health Services,
pubmed-meshheading:11924123-Time Factors,
pubmed-meshheading:11924123-Vaccines, Combined
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pubmed:year |
2002
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pubmed:articleTitle |
[Use of the multi-component VP-4 vaccine to prevent acute respiratory diseases at preschool children's establishments].
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pubmed:publicationType |
Journal Article,
English Abstract
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