Linked Life Data

11922992

Source:http://linkedlifedata.com/resource/pubmed/id/11922992

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
2002-3-29
pubmed:abstractText
NeuroD acts as one of the earliest transcription factors promoting differentiation in newborn neurons immediately after determination by neurogenin1 (ngn1). Here, we show the expression of neuroD in the 2 days postfertilization (dpf) zebrafish brain by in situ hybridization on sections. Generally, neuroD expressing cells lie one to several cell rows away from the ventricular surface, i.e., they seem to flank proliferative cells. However, most cells of the gray matter lie even more peripheral and are unstained. Highly specific local patterns of neuroD expressing cells are observed along the entire rostrocaudal zebrafish brain axis at that age with characteristic neuroD expression free zones (e.g., preoptic region and hypothalamus). Interestingly, these regions where neuroD expression is absent display a higher proliferative activity compared to neuroD-positive areas. To date it is an open question, whether this negative correlation of neuroD-expression and proliferation has a causal background.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0361-9230
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
377-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Expression domains of neuroD (nrd) in the early postembryonic zebrafish brain.
pubmed:affiliation
Brain Research Institute, University of Bremen, Bremen, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't